Recombinant multi-species Huntingtin/HTT protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Huntingtin/HTT protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. [provided by RefSeq, Jul 2016]
The Alternative Names of target: C430023I11Rik,HD,HTT,Hd,Hdh,Htt,Huntingtin,Huntington disease protein (HD protein),IT15,LOMARS

Target products collectionGo to Huntingtin/HTT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0096-Ag-1/ GM-Tg-hg-IP0096-Ag-2 Human Huntingtin/HTT protein Human
GM-Tg-rg-IP0096-Ag-1/ GM-Tg-rg-IP0096-Ag-2 Rat Huntingtin/HTT protein Rat
GM-Tg-mg-IP0096-Ag-1/ GM-Tg-mg-IP0096-Ag-2 Mouse Huntingtin/HTT protein Mouse
GM-Tg-cynog-IP0096-Ag-1/ GM-Tg-cynog-IP0096-Ag-2 Cynomolgus/Rhesus macaque Huntingtin/HTT protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0096-Ag-1/ GM-Tg-felg-IP0096-Ag-2 Feline Huntingtin/HTT protein Feline
GM-Tg-cang-IP0096-Ag-1/ GM-Tg-cang-IP0096-Ag-2 Canine Huntingtin/HTT protein Canine
GM-Tg-bovg-IP0096-Ag-1/ GM-Tg-bovg-IP0096-Ag-2 Bovine Huntingtin/HTT protein Bovine
GM-Tg-equg-IP0096-Ag-1/ GM-Tg-equg-IP0096-Ag-2 Equine Huntingtin/HTT protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0096-Ag-1/ GM-Tg-hg-IP0096-Ag-2; GM-Tg-rg-IP0096-Ag-1/ GM-Tg-rg-IP0096-Ag-2;
GM-Tg-mg-IP0096-Ag-1/ GM-Tg-mg-IP0096-Ag-2; GM-Tg-cynog-IP0096-Ag-1/ GM-Tg-cynog-IP0096-Ag-2;
GM-Tg-felg-IP0096-Ag-1/ GM-Tg-felg-IP0096-Ag-2; GM-Tg-cang-IP0096-Ag-1/ GM-Tg-cang-IP0096-Ag-2;
GM-Tg-bovg-IP0096-Ag-1/ GM-Tg-bovg-IP0096-Ag-2; GM-Tg-equg-IP0096-Ag-1/ GM-Tg-equg-IP0096-Ag-2
Products Name Huntingtin/HTT protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Huntingtin/HTT
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Huntingtin/HTT protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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