Recombinant multi-species HSD11B2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HSD11B2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
The Alternative Names of target: HSD11B2,11-beta-hydroxysteroid dehydrogenase type 2,11-DH2, 11-beta-HSD2,11-beta-hydroxysteroid dehydrogenase type II (11-HSD type II, 11-beta-HSD type II), Corticosteroid 11-beta-dehydrogenase isozyme 2, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, Short chain dehydrogenase/reductase family 9C member 3,AME,AME1,HSD2,HSD11K,SDR9C3

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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0047-Ab-1/ GM-Tg-hg-IP0047-Ab-2 Human HSD11B2 protein Human
GM-Tg-rg-IP0047-Ab-1/ GM-Tg-rg-IP0047-Ab-2 Rat HSD11B2 protein Rat
GM-Tg-mg-IP0047-Ab-1/ GM-Tg-mg-IP0047-Ab-2 Mouse HSD11B2 protein Mouse
GM-Tg-cynog-IP0047-Ab-1/ GM-Tg-cynog-IP0047-Ab-2 Cynomolgus/Rhesus macaque HSD11B2 monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0047-Ab-1/ GM-Tg-felg-IP0047-Ab-2 Feline HSD11B2 protein Feline
GM-Tg-cang-IP0047-Ab-1/ GM-Tg-cang-IP0047-Ab-2 Canine HSD11B2 protein Canine
GM-Tg-bovg-IP0047-Ab-1/ GM-Tg-bovg-IP0047-Ab-2 Bovine HSD11B2 protein Bovine
GM-Tg-equg-IP0047-Ab-1/ GM-Tg-equg-IP0047-Ab-2 Equine HSD11B2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0047-Ab-1/ GM-Tg-hg-IP0047-Ab-2; GM-Tg-rg-IP0047-Ab-1/ GM-Tg-rg-IP0047-Ab-2;
GM-Tg-mg-IP0047-Ab-1/ GM-Tg-mg-IP0047-Ab-2; GM-Tg-cynog-IP0047-Ab-1/ GM-Tg-cynog-IP0047-Ab-2;
GM-Tg-felg-IP0047-Ab-1/ GM-Tg-felg-IP0047-Ab-2; GM-Tg-cang-IP0047-Ab-1/ GM-Tg-cang-IP0047-Ab-2;
GM-Tg-bovg-IP0047-Ab-1/ GM-Tg-bovg-IP0047-Ab-2; GM-Tg-equg-IP0047-Ab-1/ GM-Tg-equg-IP0047-Ab-2
Products Name HSD11B2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name HSD11B2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HSD11B2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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