Recombinant multi-species CHEK2/RAD53 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CHEK2/RAD53 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
The Alternative Names of target: CDS1,CHEK2,CHK2,CHK2 checkpoint homolog,Cds1,Cds1 homolog (Hucds1,Checkpoint kinase 2,Chek2,Chk2,HUCDS1,HuCds1,LFS2,PP1425,RAD53,Rad53,Serine/threonine-protein kinase Chk2,TPDS4,hCds1,hCds1)

Target products collectionGo to CHEK2/RAD53 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0043-Ag-1/ GM-Tg-hg-IP0043-Ag-2 Human CHEK2/RAD53 protein Human
GM-Tg-rg-IP0043-Ag-1/ GM-Tg-rg-IP0043-Ag-2 Rat CHEK2/RAD53 protein Rat
GM-Tg-mg-IP0043-Ag-1/ GM-Tg-mg-IP0043-Ag-2 Mouse CHEK2/RAD53 protein Mouse
GM-Tg-cynog-IP0043-Ag-1/ GM-Tg-cynog-IP0043-Ag-2 Cynomolgus/Rhesus macaque CHEK2/RAD53 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0043-Ag-1/ GM-Tg-felg-IP0043-Ag-2 Feline CHEK2/RAD53 protein Feline
GM-Tg-cang-IP0043-Ag-1/ GM-Tg-cang-IP0043-Ag-2 Canine CHEK2/RAD53 protein Canine
GM-Tg-bovg-IP0043-Ag-1/ GM-Tg-bovg-IP0043-Ag-2 Bovine CHEK2/RAD53 protein Bovine
GM-Tg-equg-IP0043-Ag-1/ GM-Tg-equg-IP0043-Ag-2 Equine CHEK2/RAD53 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0043-Ag-1/ GM-Tg-hg-IP0043-Ag-2; GM-Tg-rg-IP0043-Ag-1/ GM-Tg-rg-IP0043-Ag-2;
GM-Tg-mg-IP0043-Ag-1/ GM-Tg-mg-IP0043-Ag-2; GM-Tg-cynog-IP0043-Ag-1/ GM-Tg-cynog-IP0043-Ag-2;
GM-Tg-felg-IP0043-Ag-1/ GM-Tg-felg-IP0043-Ag-2; GM-Tg-cang-IP0043-Ag-1/ GM-Tg-cang-IP0043-Ag-2;
GM-Tg-bovg-IP0043-Ag-1/ GM-Tg-bovg-IP0043-Ag-2; GM-Tg-equg-IP0043-Ag-1/ GM-Tg-equg-IP0043-Ag-2
Products Name CHEK2/RAD53 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CHEK2/RAD53
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CHEK2/RAD53 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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