Recombinant multi-species UGT1A1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine UGT1A1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq, Jul 2008]
The Alternative Names of target: BILIQTL1,Bilirubin-specific UDPGT isozyme 1 (hUG-BR1),GNT1,HUG-BR1,UDP-glucuronosyltransferase 1-1 (UDPGT 1-1,UDP-glucuronosyltransferase 1A isoform 1,UDP-glucuronosyltransferase 1A1,UDPGT,UDPGT 1-1,UGT1,UGT1*1,UGT1-01,UGT1.1),UGT1A,UGT1A1,Udpgt,Ugt1,Ugt1a1

Target products collectionGo to UGT1A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0035-Ag-1/ GM-Tg-hg-IP0035-Ag-2 Human UGT1A1 protein Human
GM-Tg-rg-IP0035-Ag-1/ GM-Tg-rg-IP0035-Ag-2 Rat UGT1A1 protein Rat
GM-Tg-mg-IP0035-Ag-1/ GM-Tg-mg-IP0035-Ag-2 Mouse UGT1A1 protein Mouse
GM-Tg-cynog-IP0035-Ag-1/ GM-Tg-cynog-IP0035-Ag-2 Cynomolgus/Rhesus macaque UGT1A1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0035-Ag-1/ GM-Tg-felg-IP0035-Ag-2 Feline UGT1A1 protein Feline
GM-Tg-cang-IP0035-Ag-1/ GM-Tg-cang-IP0035-Ag-2 Canine UGT1A1 protein Canine
GM-Tg-bovg-IP0035-Ag-1/ GM-Tg-bovg-IP0035-Ag-2 Bovine UGT1A1 protein Bovine
GM-Tg-equg-IP0035-Ag-1/ GM-Tg-equg-IP0035-Ag-2 Equine UGT1A1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0035-Ag-1/ GM-Tg-hg-IP0035-Ag-2; GM-Tg-rg-IP0035-Ag-1/ GM-Tg-rg-IP0035-Ag-2;
GM-Tg-mg-IP0035-Ag-1/ GM-Tg-mg-IP0035-Ag-2; GM-Tg-cynog-IP0035-Ag-1/ GM-Tg-cynog-IP0035-Ag-2;
GM-Tg-felg-IP0035-Ag-1/ GM-Tg-felg-IP0035-Ag-2; GM-Tg-cang-IP0035-Ag-1/ GM-Tg-cang-IP0035-Ag-2;
GM-Tg-bovg-IP0035-Ag-1/ GM-Tg-bovg-IP0035-Ag-2; GM-Tg-equg-IP0035-Ag-1/ GM-Tg-equg-IP0035-Ag-2
Products Name UGT1A1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name UGT1A1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine UGT1A1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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