Recombinant multi-species BAX protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BAX protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. The association and the ratio of BAX to BCL2 also determines survival or death of a cell following an apoptotic stimulus. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Dec 2019]
The Alternative Names of target: Apoptosis regulator BAX,BAX,BCL2L4,Bax,Bcl-2-like protein 4 (Bcl2-L-4)

Target products collectionGo to BAX products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0034-Ag-1/ GM-Tg-hg-IP0034-Ag-2 Human BAX protein Human
GM-Tg-rg-IP0034-Ag-1/ GM-Tg-rg-IP0034-Ag-2 Rat BAX protein Rat
GM-Tg-mg-IP0034-Ag-1/ GM-Tg-mg-IP0034-Ag-2 Mouse BAX protein Mouse
GM-Tg-cynog-IP0034-Ag-1/ GM-Tg-cynog-IP0034-Ag-2 Cynomolgus/Rhesus macaque BAX protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0034-Ag-1/ GM-Tg-felg-IP0034-Ag-2 Feline BAX protein Feline
GM-Tg-cang-IP0034-Ag-1/ GM-Tg-cang-IP0034-Ag-2 Canine BAX protein Canine
GM-Tg-bovg-IP0034-Ag-1/ GM-Tg-bovg-IP0034-Ag-2 Bovine BAX protein Bovine
GM-Tg-equg-IP0034-Ag-1/ GM-Tg-equg-IP0034-Ag-2 Equine BAX protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0034-Ag-1/ GM-Tg-hg-IP0034-Ag-2; GM-Tg-rg-IP0034-Ag-1/ GM-Tg-rg-IP0034-Ag-2;
GM-Tg-mg-IP0034-Ag-1/ GM-Tg-mg-IP0034-Ag-2; GM-Tg-cynog-IP0034-Ag-1/ GM-Tg-cynog-IP0034-Ag-2;
GM-Tg-felg-IP0034-Ag-1/ GM-Tg-felg-IP0034-Ag-2; GM-Tg-cang-IP0034-Ag-1/ GM-Tg-cang-IP0034-Ag-2;
GM-Tg-bovg-IP0034-Ag-1/ GM-Tg-bovg-IP0034-Ag-2; GM-Tg-equg-IP0034-Ag-1/ GM-Tg-equg-IP0034-Ag-2
Products Name BAX protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name BAX
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BAX protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.