Recombinant multi-species HMGCR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HMGCR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
The Alternative Names of target: 3-hydroxy-3-methylglutaryl-coenzyme A reductase,3H3M,HMG-CoA reductase,HMG-CoAR,HMGCR,Hmgcr,LDLCQ3,LGMDR28,MYPLG,Red,hmg-coa-r

Target products collectionGo to HMGCR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0005-Ag-1/ GM-Tg-hg-IP0005-Ag-2 Human HMGCR protein Human
GM-Tg-rg-IP0005-Ag-1/ GM-Tg-rg-IP0005-Ag-2 Rat HMGCR protein Rat
GM-Tg-mg-IP0005-Ag-1/ GM-Tg-mg-IP0005-Ag-2 Mouse HMGCR protein Mouse
GM-Tg-cynog-IP0005-Ag-1/ GM-Tg-cynog-IP0005-Ag-2 Cynomolgus/Rhesus macaque HMGCR protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0005-Ag-1/ GM-Tg-felg-IP0005-Ag-2 Feline HMGCR protein Feline
GM-Tg-cang-IP0005-Ag-1/ GM-Tg-cang-IP0005-Ag-2 Canine HMGCR protein Canine
GM-Tg-bovg-IP0005-Ag-1/ GM-Tg-bovg-IP0005-Ag-2 Bovine HMGCR protein Bovine
GM-Tg-equg-IP0005-Ag-1/ GM-Tg-equg-IP0005-Ag-2 Equine HMGCR protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0005-Ag-1/ GM-Tg-hg-IP0005-Ag-2; GM-Tg-rg-IP0005-Ag-1/ GM-Tg-rg-IP0005-Ag-2;
GM-Tg-mg-IP0005-Ag-1/ GM-Tg-mg-IP0005-Ag-2; GM-Tg-cynog-IP0005-Ag-1/ GM-Tg-cynog-IP0005-Ag-2;
GM-Tg-felg-IP0005-Ag-1/ GM-Tg-felg-IP0005-Ag-2; GM-Tg-cang-IP0005-Ag-1/ GM-Tg-cang-IP0005-Ag-2;
GM-Tg-bovg-IP0005-Ag-1/ GM-Tg-bovg-IP0005-Ag-2; GM-Tg-equg-IP0005-Ag-1/ GM-Tg-equg-IP0005-Ag-2
Products Name HMGCR protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name HMGCR
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HMGCR protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

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    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.