Recombinant multi-species IRE1/ERN1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IRE1/ERN1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017]
The Alternative Names of target: 9030414B18Rik,ERN1,Endoplasmic reticulum-to-nucleus signaling 1,Ern1,IRE1,IRE1P,IRE1a,Inositol-requiring protein 1 (hIRE1p),Ire1-alpha (IRE1a),Ire1a,Ire1alpha,Ire1p,RGD1559716,Serine/threonine-protein kinase/endoribonuclease IRE1,hIRE1p

Target products collectionGo to IRE1/ERN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0001-Ag-1/ GM-Tg-hg-IP0001-Ag-2 Human IRE1/ERN1 protein Human
GM-Tg-rg-IP0001-Ag-1/ GM-Tg-rg-IP0001-Ag-2 Rat IRE1/ERN1 protein Rat
GM-Tg-mg-IP0001-Ag-1/ GM-Tg-mg-IP0001-Ag-2 Mouse IRE1/ERN1 protein Mouse
GM-Tg-cynog-IP0001-Ag-1/ GM-Tg-cynog-IP0001-Ag-2 Cynomolgus/Rhesus macaque IRE1/ERN1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0001-Ag-1/ GM-Tg-felg-IP0001-Ag-2 Feline IRE1/ERN1 protein Feline
GM-Tg-cang-IP0001-Ag-1/ GM-Tg-cang-IP0001-Ag-2 Canine IRE1/ERN1 protein Canine
GM-Tg-bovg-IP0001-Ag-1/ GM-Tg-bovg-IP0001-Ag-2 Bovine IRE1/ERN1 protein Bovine
GM-Tg-equg-IP0001-Ag-1/ GM-Tg-equg-IP0001-Ag-2 Equine IRE1/ERN1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0001-Ag-1/ GM-Tg-hg-IP0001-Ag-2; GM-Tg-rg-IP0001-Ag-1/ GM-Tg-rg-IP0001-Ag-2;
GM-Tg-mg-IP0001-Ag-1/ GM-Tg-mg-IP0001-Ag-2; GM-Tg-cynog-IP0001-Ag-1/ GM-Tg-cynog-IP0001-Ag-2;
GM-Tg-felg-IP0001-Ag-1/ GM-Tg-felg-IP0001-Ag-2; GM-Tg-cang-IP0001-Ag-1/ GM-Tg-cang-IP0001-Ag-2;
GM-Tg-bovg-IP0001-Ag-1/ GM-Tg-bovg-IP0001-Ag-2; GM-Tg-equg-IP0001-Ag-1/ GM-Tg-equg-IP0001-Ag-2
Products Name IRE1/ERN1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name IRE1/ERN1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IRE1/ERN1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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