Recombinant multi-species ERG protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ERG protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]
The Alternative Names of target: D030036I24Rik,ERG,Erg,LMPHM14,Transcriptional regulator ERG,Transforming protein ERG,erg-3,p55

Target products collectionGo to ERG products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IO040-Ag-1/ GM-Tg-hg-IO040-Ag-2 Human ERG protein Human
GM-Tg-rg-IO040-Ag-1/ GM-Tg-rg-IO040-Ag-2 Rat ERG protein Rat
GM-Tg-mg-IO040-Ag-1/ GM-Tg-mg-IO040-Ag-2 Mouse ERG protein Mouse
GM-Tg-cynog-IO040-Ag-1/ GM-Tg-cynog-IO040-Ag-2 Cynomolgus/Rhesus macaque ERG protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IO040-Ag-1/ GM-Tg-felg-IO040-Ag-2 Feline ERG protein Feline
GM-Tg-cang-IO040-Ag-1/ GM-Tg-cang-IO040-Ag-2 Canine ERG protein Canine
GM-Tg-bovg-IO040-Ag-1/ GM-Tg-bovg-IO040-Ag-2 Bovine ERG protein Bovine
GM-Tg-equg-IO040-Ag-1/ GM-Tg-equg-IO040-Ag-2 Equine ERG protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IO040-Ag-1/ GM-Tg-hg-IO040-Ag-2; GM-Tg-rg-IO040-Ag-1/ GM-Tg-rg-IO040-Ag-2;
GM-Tg-mg-IO040-Ag-1/ GM-Tg-mg-IO040-Ag-2; GM-Tg-cynog-IO040-Ag-1/ GM-Tg-cynog-IO040-Ag-2;
GM-Tg-felg-IO040-Ag-1/ GM-Tg-felg-IO040-Ag-2; GM-Tg-cang-IO040-Ag-1/ GM-Tg-cang-IO040-Ag-2;
GM-Tg-bovg-IO040-Ag-1/ GM-Tg-bovg-IO040-Ag-2; GM-Tg-equg-IO040-Ag-1/ GM-Tg-equg-IO040-Ag-2
Products Name ERG protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ERG
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ERG protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.