Explore IDH3G gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined. [provided by RefSeq, Jul 2008]
| Target ID |
GM-TA181
|
| Target Name |
IDH3G
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3421
|
| Gene ID |
100057896 (Equus caballus), 102902308 (Felis catus), 15929 (Mus musculus), 25179 (Rattus norvegicus) 3421 (Homo sapiens), 481081 (Canis lupus familiaris), 614145 (Bos taurus), 698558 (Macaca mulatta)
|
| Target Alternative Names |
H-IDHG,IDH,IDH3G,Idh3g,Isocitrate dehydrogenase [NAD] subunit gamma,Isocitric dehydrogenase subunit gamma,NAD(+)-specific ICDH subunit gamma,mitochondrial
|
| Uniprot Accession |
P70404,P41565,P51553,Q58CP0
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Metabolic pathways
|
| Gene Ensembl |
ENSECAG00000018509, ENSMUSG00000002010, ENSG00000067829, ENSCAFG00845025145, ENSBTAG00000001059, ENSMMUG00000003374
|
IDH3G siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3421 | Pre-made Human IDH3G/H-IDHG siRNA oligo Duplex | 3421 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25179 | Pre-made Rat Idh3g/IDH siRNA oligo Duplex | 25179 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo15929 | Pre-made Mouse Idh3g siRNA oligo Duplex | 15929 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo698558 | Pre-made Cynomolgus/Rhesus macaque IDH3G siRNA oligo Duplex | 698558 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo102902308 | Pre-made Cat/Feline IDH3G siRNA oligo Duplex | 102902308 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo481081 | Pre-made Dog/Canine IDH3G siRNA oligo Duplex | 481081 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo614145 | Pre-made Bovines/Cattle IDH3G siRNA oligo Duplex | 614145 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100057896 | Pre-made Equine/Horse IDH3G siRNA oligo Duplex | 100057896 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IDH3G antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-TA181-Ab | Human | Anti-Human IDH3G monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-TA181-Ab | Rat | Anti-Rat IDH3G monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-TA181-Ab | Mouse | Anti-Mouse IDH3G monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-TA181-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IDH3G monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-TA181-Ab | Cat/Feline | Anti-Cat/Feline IDH3G monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-TA181-Ab | Dog/Canine | Anti-Dog/Canine IDH3G monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-TA181-Ab | Bovines/Cattle | Anti-Bovines/Cattle IDH3G monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-TA181-Ab | Equine/Horse | Anti-Equine/Horse IDH3G monoclonal antibody | mab | Therapeutics Target antibody | Detail |
IDH3G recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-TA181-Ag | Human | Human IDH3G recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-TA181-Ag | Rat | Rat IDH3G recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-TA181-Ag | Mouse | Mouse IDH3G recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-TA181-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IDH3G recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-TA181-Ag | Cat/Feline | Cat/Feline IDH3G recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-TA181-Ag | Dog/Canine | Dog/Canine IDH3G recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-TA181-Ag | Bovines/Cattle | Bovines/Cattle IDH3G recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-TA181-Ag | Equine/Horse | Equine/Horse IDH3G recombinant protein | Mammalian cell | Detail |