Explore HLA-DRB5 gene products and cross-species
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Target
sublocation: Transmembrane Protein.
HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene. [provided by RefSeq, Feb 2020]
| Target ID |
GM-TA180
|
| Target Name |
HLA-DRB5
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3127
|
| Gene ID |
3127 (Homo sapiens)
|
| Target Alternative Names |
DR beta 5 chain,DR beta-5,DR2-beta-2,DRB5,Dw2,HLA class II histocompatibility antigen,HLA-DRB5,HLA-DRB5*,MHC class II antigen DRB5
|
| Uniprot Accession |
Q30154
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Phagosome, Cell adhesion molecules, Antigen processing and presentation, Hematopoietic cell lineage, Th1 and Th2 cell differentiation, Th17 cell differentiation, Intestinal immune network for IgA production, Type I diabetes mellitus, Leishmaniasis, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Influenza A, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection, Asthma, Autoimmune thyroid disease, Inflammatory bowel disease, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Viral myocarditis
|
| Gene Ensembl |
ENSG00000198502
|
Pre-made viral vector of HLA-DRB5 cDNA Clones/ORF Plasmid
HLA-DRB5 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3127 | Pre-made Human HLA-DRB5/DRB5/HLA-DRB5* siRNA oligo Duplex | 3127 | Human | In-vitro grade; in-vivo grade | Detail |
HLA-DRB5 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-TA180-Ab | Human | Anti-Human HLA-DRB5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
HLA-DRB5 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-TA180-Ag | Human | Human HLA-DRB5 VLP (virus-like particle) | HEK293 | Products Developing |
