Explore IDH3B gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2016]
| Target ID |
GM-TA170
|
| Target Name |
IDH3B
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3420
|
| Gene ID |
100052969 (Equus caballus), 101099035 (Felis catus), 170718 (Mus musculus), 3420 (Homo sapiens) 477177 (Canis lupus familiaris), 613338 (Bos taurus), 716726 (Macaca mulatta), 94173 (Rattus norvegicus)
|
| Target Alternative Names |
IDH1,IDH3,IDH3B,Idh3b,Isocitrate dehydrogenase [NAD] subunit beta,Isocitric dehydrogenase subunit beta,NAD(+)-specific ICDH subunit beta,RP46,mitochondrial
|
| Uniprot Accession |
O43837,O77784,Q68FX0
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Metabolic pathways
|
| Gene Ensembl |
ENSECAG00000000261, ENSMUSG00000027406, ENSG00000101365, ENSCAFG00845016410, ENSBTAG00000018813, ENSMMUG00000021328
|
IDH3B siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3420 | Pre-made Human IDH3B/RP46 siRNA oligo Duplex | 3420 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo94173 | Pre-made Rat Idh3b siRNA oligo Duplex | 94173 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo170718 | Pre-made Mouse Idh3b siRNA oligo Duplex | 170718 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo716726 | Pre-made Cynomolgus/Rhesus macaque IDH3B siRNA oligo Duplex | 716726 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101099035 | Pre-made Cat/Feline IDH3B siRNA oligo Duplex | 101099035 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo477177 | Pre-made Dog/Canine IDH3B siRNA oligo Duplex | 477177 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo613338 | Pre-made Bovines/Cattle IDH3B/IDH1/IDH3 siRNA oligo Duplex | 613338 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100052969 | Pre-made Equine/Horse IDH3B siRNA oligo Duplex | 100052969 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IDH3B antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-TA170-Ab | Human | Anti-Human IDH3B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-TA170-Ab | Rat | Anti-Rat IDH3B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-TA170-Ab | Mouse | Anti-Mouse IDH3B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-TA170-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IDH3B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-TA170-Ab | Cat/Feline | Anti-Cat/Feline IDH3B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-TA170-Ab | Dog/Canine | Anti-Dog/Canine IDH3B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-TA170-Ab | Bovines/Cattle | Anti-Bovines/Cattle IDH3B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-TA170-Ab | Equine/Horse | Anti-Equine/Horse IDH3B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
IDH3B recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-TA170-Ag | Human | Human IDH3B recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-TA170-Ag | Rat | Rat IDH3B recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-TA170-Ag | Mouse | Mouse IDH3B recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-TA170-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IDH3B recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-TA170-Ag | Cat/Feline | Cat/Feline IDH3B recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-TA170-Ag | Dog/Canine | Dog/Canine IDH3B recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-TA170-Ag | Bovines/Cattle | Bovines/Cattle IDH3B recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-TA170-Ag | Equine/Horse | Equine/Horse IDH3B recombinant protein | Mammalian cell | Detail |