NF-κB p65/RELA Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein
Explore NF-κB p65/RELA gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
| Target ID | GM-TA153 |
| Target Name | NF-κB p65/RELA |
|
Gene Group ldentifer （Target Gene ID in Homo species) |
5970 |
| Gene ID |
100057483 (Equus caballus), 101096604 (Felis catus), 19697 (Mus musculus), 309165 (Rattus norvegicus) 483729 (Canis lupus familiaris), 508233 (Bos taurus), 5970 (Homo sapiens), 715919 (Macaca mulatta) |
| Target Alternative Names | AIF3BL3,CMCU,NF-κB p65,NFKB3,NFkB,Nuclear factor NF-kappa-B p65 subunit,Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3,RELA,Rela,Transcription factor p65,nos2,p65,p65 NF-kappa B,p65 NFkB |
| Uniprot Accession | Q04207,Q04206 |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | cancer |
| Disease from KEGG | Antifolate resistance, MAPK signaling pathway, Ras signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, NF-kappa B signaling pathway, HIF-1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Apoptosis, Longevity regulating pathway, Cellular senescence, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, TNF signaling pathway, Neurotrophin signaling pathway, Prolactin signaling pathway, Adipocytokine signaling pathway, Relaxin signaling pathway, Insulin resistance, AGE-RAGE signaling pathway in diabetic complications, Alcoholic liver disease, Alzheimer disease, Cocaine addiction, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Pathways in cancer, Chemical carcinogenesis - receptor activation, Pancreatic cancer, Prostate cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Inflammatory bowel disease, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis |
| Gene Ensembl | ENSECAG00000013763, ENSMUSG00000024927, ENSCAFG00845019016, ENSBTAG00000013895, ENSG00000173039, ENSMMUG00000007418 |
| Target Classification | Tumor-associated antigen (TAA) |
Pre-made viral vector of NF-κB p65/RELA cDNA Clones/ORF Plasmid
| Cat No. | Product Name | NMID | GeneID | Species | Type | Marker | Fusion Tag | Promoter | Detail |
|---|---|---|---|---|---|---|---|---|---|
| pGMLP001097 | Human RELA/NFKB3/p65 Lentivirus plasmid | NM_001145138 | 5970 | Human | Lentivirus plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| pGMLV001194 | Human RELA/CMCU/NFKB3 Lentivirus plasmid | NM_021975.4 | 5970 | Human | Lentivirus plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| pGMAD000732 | Human RELA/CMCU/NFKB3 Adenovirus plasmid | NM_021975.4 | 5970 | Human | Adenovirus plasmid | EGFP | 3xflag (C-Terminal) | EF1 | Detail |
| pGMPC000194 | Human RELA/CMCU/NFKB3 Mammalian (Non-Viral Vector) plasmid | NM_021975.4 | 5970 | Human | Mammalian (Non-Viral Vector) plasmid | Null | HA (C-Terminal) | CMV | Detail |
| pGMPC000215 | Human RELA/CMCU/NFKB3 Mammalian (Non-Viral Vector) plasmid | NM_001145138.2 | 5970 | Human | Mammalian (Non-Viral Vector) plasmid | EGFP | 3xflag (C-Terminal) | EF1 | Detail |
| pGMPC000396 | Human RELA/CMCU/NFKB3 Mammalian (Non-Viral Vector) plasmid | NM_021975 | 5970 | Human | Mammalian (Non-Viral Vector) plasmid | EGFP | Null | EF1 | Detail |
| pGMPC000552 | Human RELA/CMCU/NFKB3 Mammalian (Non-Viral Vector) plasmid | NM_021975 | 5970 | Human | Mammalian (Non-Viral Vector) plasmid | ZsGreen | HA (C-Terminal) | CMV | Detail |
| vGMLP001097 | Human RELA/NFKB3/p65 Lentivirus particle | NM_001145138 | 5970 | Human | Lentivirus particle | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| vGMLV001194 | Human RELA/CMCU/NFKB3 Lentivirus particle | NM_021975.4 | 5970 | Human | Lentivirus particle | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| vGMAD000732 | Human RELA/CMCU/NFKB3 Adenovirus particle | NM_021975.4 | 5970 | Human | Adenovirus particle | EGFP | 3xflag (C-Terminal) | EF1 | Detail |
| pGMLPm002052 | Mouse Rela/p65 Lentivirus plasmid | NM_009045 | 19697 | Mouse | Lentivirus plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| vGMLPm002052 | Mouse Rela/p65 Lentivirus particle | NM_009045 | 19697 | Mouse | Lentivirus particle | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| pGMAD001339 | Cattle RELA Adenovirus plasmid | NM_001080242.2 | 508233 | Cattle | Adenovirus plasmid | EGFP | 3xflag (C-Terminal) | EF1 | Detail |
| vGMAD001339 | Cattle RELA Adenovirus particle | NM_001080242.2 | 508233 | Cattle | Adenovirus particle | EGFP | 3xflag (C-Terminal) | EF1 | Detail |
NF-κB p65/RELA siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|---|---|---|---|---|
| pGMoligo5970 | Pre-made Human RELA/p65/CMCU siRNA oligo Duplex | 5970 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo309165 | Pre-made Rat Rela/NFkB/nos2 siRNA oligo Duplex | 309165 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19697 | Pre-made Mouse Rela/p65/p65 NFkB siRNA oligo Duplex | 19697 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo715919 | Pre-made Cynomolgus/Rhesus macaque RELA siRNA oligo Duplex | 715919 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101096604 | Pre-made Cat/Feline RELA siRNA oligo Duplex | 101096604 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo483729 | Pre-made Dog/Canine RELA siRNA oligo Duplex | 483729 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo508233 | Pre-made Bovines/Cattle RELA siRNA oligo Duplex | 508233 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100057483 | Pre-made Equine/Horse RELA siRNA oligo Duplex | 100057483 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
NF-κB p65/RELA antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|---|---|---|---|---|
| GM-Tg-hg-TA153-Ab | Human | Anti-Human NF-κB p65/RELA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-TA153-Ab | Rat | Anti-Rat NF-κB p65/RELA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-TA153-Ab | Mouse | Anti-Mouse NF-κB p65/RELA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-TA153-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque NF-κB p65/RELA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-TA153-Ab | Cat/Feline | Anti-Cat/Feline NF-κB p65/RELA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-TA153-Ab | Dog/Canine | Anti-Dog/Canine NF-κB p65/RELA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-TA153-Ab | Bovines/Cattle | Anti-Bovines/Cattle NF-κB p65/RELA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-TA153-Ab | Equine/Horse | Anti-Equine/Horse NF-κB p65/RELA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
NF-κB p65/RELA recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|---|---|---|---|
| GM-Tg-hg-TA153-Ag | Human | Human NF-κB p65/RELA recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-TA153-Ag | Rat | Rat NF-κB p65/RELA recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-TA153-Ag | Mouse | Mouse NF-κB p65/RELA recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-TA153-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque NF-κB p65/RELA recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-TA153-Ag | Cat/Feline | Cat/Feline NF-κB p65/RELA recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-TA153-Ag | Dog/Canine | Dog/Canine NF-κB p65/RELA recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-TA153-Ag | Bovines/Cattle | Bovines/Cattle NF-κB p65/RELA recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-TA153-Ag | Equine/Horse | Equine/Horse NF-κB p65/RELA recombinant protein | Mammalian cell | Detail |