Nicastrin/NCSTN Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore Nicastrin/NCSTN gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Transmembrane Protein.
This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]

Pre-made viral vector of Nicastrin/NCSTN cDNA Clones/ORF Plasmid

Nicastrin/NCSTN siRNA/miRNA/oligo for RNA interfence (RNAi)

Nicastrin/NCSTN antibody/GMab

Nicastrin/NCSTN VLP (virus-like particle)/protein