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Target
sublocation: Transmembrane Protein.
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| Target ID |
GM-TA129
|
| Target Name |
LILRB3/CD85a
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
11025
|
| Gene ID |
106992409 (Macaca mulatta), 11025 (Homo sapiens)
|
| Target Alternative Names |
CD85 antigen-like family member A,CD85A,CD85a,HL9,ILT-5,ILT5,Immunoglobulin-like transcript 5 (ILT-5),LILRA6,LILRB3,LIR-3,LIR3,Leukocyte immunoglobulin-like receptor 3,Leukocyte immunoglobulin-like receptor subfamily B member 3,Monocyte inhibitory receptor HL9,PIR-B,PIRB
|
| Uniprot Accession |
O75022
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Osteoclast differentiation, B cell receptor signaling pathway
|
| Gene Ensembl |
ENSMMUG00000048321, ENSG00000204577
|
Pre-made viral vector of LILRB3/CD85a cDNA Clones/ORF Plasmid
LILRB3/CD85a siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo11025 | Pre-made Human LILRB3/HL9/ILT5 siRNA oligo Duplex | 11025 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo106992409 | Pre-made Cynomolgus/Rhesus macaque LILRB3 siRNA oligo Duplex | 106992409 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
LILRB3/CD85a antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-TA129-Ab | Human | Anti-Human LILRB3/CD85a monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-TA129-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque LILRB3/CD85a monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
LILRB3/CD85a VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-TA129-Ag | Human | Human LILRB3/CD85a VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-TA129-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque LILRB3/CD85a VLP (virus-like particle) | HEK293 | Products Developing |
