Explore PLCG1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| Target ID |
GM-TA050
|
| Target Name |
PLCG1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5335
|
| Gene ID |
100070545 (Equus caballus), 101092925 (Felis catus), 18803 (Mus musculus), 25738 (Rattus norvegicus)
281987 (Bos taurus), 485874 (Canis lupus familiaris), 5335 (Homo sapiens), 697069 (Macaca mulatta)
|
| Target Alternative Names |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1,Cded,IDAA,NCKAP3,PLC-148,PLC-II,PLC1,PLC148,PLCG1,PLCgamma1,PPLCA,Phosphoinositide phospholipase C-gamma-1,Phospholipase C-II (PLC-II),Phospholipase C-gamma-1 (PLC-gamma-1),Plc-1,Plc-gamma1,Plcg-1,Plcg1
|
| Uniprot Accession |
Q62077,P10686,P08487,P19174
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Metabolic pathways, EGFR tyrosine kinase inhibitor resistance, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Chemokine signaling pathway, NF-kappa B signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, Axon guidance, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Leukocyte transendothelial migration, Neurotrophin signaling pathway, Inflammatory mediator regulation of TRP channels, Thyroid hormone signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Growth hormone synthesis, secretion and action, Epithelial cell signaling in Helicobacter pylori infection, Yersinia infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Proteoglycans in cancer, Glioma, Non-small cell lung cancer, Hepatocellular carcinoma, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000021031, ENSMUSG00000016933, ENSBTAG00000017584, ENSCAFG00845030031, ENSG00000124181, ENSMMUG00000005905
|
PLCG1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5335 | Pre-made Human PLCG1/IDAA/PLC1 siRNA oligo Duplex | 5335 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25738 | Pre-made Rat Plcg1/PPLCA siRNA oligo Duplex | 25738 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18803 | Pre-made Mouse Plcg1/Cded/Plc-1 siRNA oligo Duplex | 18803 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo697069 | Pre-made Cynomolgus/Rhesus macaque PLCG1 siRNA oligo Duplex | 697069 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101092925 | Pre-made Cat/Feline PLCG1 siRNA oligo Duplex | 101092925 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo485874 | Pre-made Dog/Canine PLCG1 siRNA oligo Duplex | 485874 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281987 | Pre-made Bovines/Cattle PLCG1 siRNA oligo Duplex | 281987 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100070545 | Pre-made Equine/Horse PLCG1 siRNA oligo Duplex | 100070545 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PLCG1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-TA050-Ab | Human | Anti-Human PLCG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-TA050-Ab | Rat | Anti-Rat PLCG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-TA050-Ab | Mouse | Anti-Mouse PLCG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-TA050-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PLCG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-TA050-Ab | Cat/Feline | Anti-Cat/Feline PLCG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-TA050-Ab | Dog/Canine | Anti-Dog/Canine PLCG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-TA050-Ab | Bovines/Cattle | Anti-Bovines/Cattle PLCG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-TA050-Ab | Equine/Horse | Anti-Equine/Horse PLCG1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
PLCG1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-TA050-Ag | Human | Human PLCG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-TA050-Ag | Rat | Rat PLCG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-TA050-Ag | Mouse | Mouse PLCG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-TA050-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PLCG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-TA050-Ag | Cat/Feline | Cat/Feline PLCG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-TA050-Ag | Dog/Canine | Dog/Canine PLCG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-TA050-Ag | Bovines/Cattle | Bovines/Cattle PLCG1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-TA050-Ag | Equine/Horse | Equine/Horse PLCG1 recombinant protein | Mammalian cell | Detail |
