Explore CD126/IL-6R alpha/IL6R gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, Aug 2020]
| Target ID |
GM-TA027
|
| Target Name |
CD126/IL-6R alpha/IL6R
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3570
|
| Gene ID |
101085689 (Felis catus), 102148787 (Equus caballus), 16194 (Mus musculus), 24499 (Rattus norvegicus) 3570 (Homo sapiens), 507359 (Bos taurus), 612271 (Canis lupus familiaris), 716690 (Macaca mulatta)
|
| Target Alternative Names |
CD126,HIES5,IL-1Ra,IL-6 receptor subunit alpha,IL-6R,IL-6R 1,IL-6R alpha,IL-6R subunit alpha,IL-6R-1,IL-6R-alpha,IL-6RA,IL6Q,IL6QTL,IL6R,IL6R1,IL6RA,IL6RQ,Il6r,Il6ra,Interleukin-6 receptor subunit alpha,Membrane glycoprotein 80 (gp80),gp80
|
| Uniprot Accession |
P22272,P22273,P08887
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
|
| Disease |
cancer, Ovary Cancer, myeloma patients
|
| Disease from KEGG |
EGFR tyrosine kinase inhibitor resistance, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, HIF-1 signaling pathway, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Hematopoietic cell lineage, Th17 cell differentiation, Human cytomegalovirus infection, Pathways in cancer
|
| Gene Ensembl |
ENSECAG00000024047, ENSMUSG00000027947, ENSG00000160712, ENSBTAG00000018474, ENSCAFG00845014397, ENSMMUG00000022978
|
| Target Classification |
Cytokine Receptor, Checkpoint-Immuno Oncology
|
Pre-made viral vector of CD126/IL-6R alpha/IL6R cDNA Clones/ORF Plasmid
CD126/IL-6R alpha/IL6R siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3570 | Pre-made Human IL6R/IL6Q/gp80 siRNA oligo Duplex | 3570 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24499 | Pre-made Rat Il6r/IL6R1/Il6ra siRNA oligo Duplex | 24499 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16194 | Pre-made Mouse Il6ra/Il6r/CD126 siRNA oligo Duplex | 16194 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo716690 | Pre-made Cynomolgus/Rhesus macaque IL6R siRNA oligo Duplex | 716690 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101085689 | Pre-made Cat/Feline IL6R siRNA oligo Duplex | 101085689 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo612271 | Pre-made Dog/Canine IL6R siRNA oligo Duplex | 612271 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo507359 | Pre-made Bovines/Cattle IL6R siRNA oligo Duplex | 507359 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo102148787 | Pre-made Equine/Horse IL6R siRNA oligo Duplex | 102148787 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CD126/IL-6R alpha/IL6R antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-TA027-Ab | Human | Anti-Human CD126/IL-6R alpha/IL6R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-TA027-Ab | Rat | Anti-Rat CD126/IL-6R alpha/IL6R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-TA027-Ab | Mouse | Anti-Mouse CD126/IL-6R alpha/IL6R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-TA027-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CD126/IL-6R alpha/IL6R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-TA027-Ab | Cat/Feline | Anti-Cat/Feline CD126/IL-6R alpha/IL6R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-TA027-Ab | Dog/Canine | Anti-Dog/Canine CD126/IL-6R alpha/IL6R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-TA027-Ab | Bovines/Cattle | Anti-Bovines/Cattle CD126/IL-6R alpha/IL6R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-TA027-Ab | Equine/Horse | Anti-Equine/Horse CD126/IL-6R alpha/IL6R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
CD126/IL-6R alpha/IL6R VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-TA027-Ag | Human | Human CD126/IL-6R alpha/IL6R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-TA027-Ag | Rat | Rat CD126/IL-6R alpha/IL6R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-TA027-Ag | Mouse | Mouse CD126/IL-6R alpha/IL6R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-TA027-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CD126/IL-6R alpha/IL6R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-TA027-Ag | Cat/Feline | Cat/Feline CD126/IL-6R alpha/IL6R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-TA027-Ag | Dog/Canine | Dog/Canine CD126/IL-6R alpha/IL6R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-TA027-Ag | Bovines/Cattle | Bovines/Cattle CD126/IL-6R alpha/IL6R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-TA027-Ag | Equine/Horse | Equine/Horse CD126/IL-6R alpha/IL6R VLP (virus-like particle) | HEK293 | Products Developing |