CD126/IL-6R alpha/IL6R Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore CD126/IL-6R alpha/IL6R gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Transmembrane Protein.
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, Aug 2020]

Target ID GM-TA027
Target Name CD126/IL-6R alpha/IL6R
Gene Group ldentifer
(Target Gene ID in Homo species)
3570
Gene ID 101085689 (Felis catus), 102148787 (Equus caballus), 16194 (Mus musculus), 24499 (Rattus norvegicus)
3570 (Homo sapiens), 507359 (Bos taurus), 612271 (Canis lupus familiaris), 716690 (Macaca mulatta)
Target Alternative Names CD126,HIES5,IL-1Ra,IL-6 receptor subunit alpha,IL-6R,IL-6R 1,IL-6R alpha,IL-6R subunit alpha,IL-6R-1,IL-6R-alpha,IL-6RA,IL6Q,IL6QTL,IL6R,IL6R1,IL6RA,IL6RQ,Il6r,Il6ra,Interleukin-6 receptor subunit alpha,Membrane glycoprotein 80 (gp80),gp80
Uniprot Accession P22272,P22273,P08887
Protein Sub-location Transmembrane Protein
Category Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
Disease cancer, Ovary Cancer, myeloma patients
Disease from KEGG EGFR tyrosine kinase inhibitor resistance, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, HIF-1 signaling pathway, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Hematopoietic cell lineage, Th17 cell differentiation, Human cytomegalovirus infection, Pathways in cancer
Gene Ensembl ENSECAG00000024047, ENSMUSG00000027947, ENSG00000160712, ENSBTAG00000018474, ENSCAFG00845014397, ENSMMUG00000022978
Target Classification Cytokine Receptor, Checkpoint-Immuno Oncology


Pre-made viral vector of CD126/IL-6R alpha/IL6R cDNA Clones/ORF Plasmid

Cat No.Product NameNMIDGeneIDSpeciesTypeMarkerFusion TagPromoterDetail
pGMLP000774Human IL6R/CD126/gp80 Lentivirus plasmidNM_0005653570HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
pGMLV002570Human IL6R/CD126/gp80 Lentivirus plasmidNM_0005653570HumanLentivirus plasmidNull3xflag (C-Terminal)CMVDetail
vGMLP000774Human IL6R/CD126/gp80 Lentivirus particleNM_0005653570HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
vGMLV002570Human IL6R/CD126/gp80 Lentivirus particleNM_0005653570HumanLentivirus particleNull3xflag (C-Terminal)CMVDetail
pGMLV002569Mouse Il6ra/CD126/IL-6R Lentivirus plasmidNM_001310676.116194MouseLentivirus plasmidNull3xflag (C-Terminal)CMVDetail
pGMLPm002017Mouse Il6ra/CD126/IL-6R Lentivirus plasmidNM_001310676.116194MouseLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
vGMLV002569Mouse Il6ra/CD126/IL-6R Lentivirus particleNM_001310676.116194MouseLentivirus particleNull3xflag (C-Terminal)CMVDetail
vGMLPm002017Mouse Il6ra/CD126/IL-6R Lentivirus particleNM_001310676.116194MouseLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail


CD126/IL-6R alpha/IL6R siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.Product NameGeneIDSpeciesGradeDetail
pGMoligo3570Pre-made Human IL6R/IL6Q/gp80 siRNA oligo Duplex3570HumanIn-vitro grade; in-vivo gradeDetail
pGMoligo24499Pre-made Rat Il6r/IL6R1/Il6ra siRNA oligo Duplex24499RatIn-vitro grade; in-vivo gradeDetail
pGMoligo16194Pre-made Mouse Il6ra/Il6r/CD126 siRNA oligo Duplex16194MouseIn-vitro grade; in-vivo gradeDetail
pGMoligo716690Pre-made Cynomolgus/Rhesus macaque IL6R siRNA oligo Duplex716690Cynomolgus/Rhesus macaqueIn-vitro grade; in-vivo gradeDetail
pGMoligo101085689Pre-made Cat/Feline IL6R siRNA oligo Duplex101085689Cat/FelineIn-vitro grade; in-vivo gradeDetail
pGMoligo612271Pre-made Dog/Canine IL6R siRNA oligo Duplex612271Dog/CanineIn-vitro grade; in-vivo gradeDetail
pGMoligo507359Pre-made Bovines/Cattle IL6R siRNA oligo Duplex507359Bovines/CattleIn-vitro grade; in-vivo gradeDetail
pGMoligo102148787Pre-made Equine/Horse IL6R siRNA oligo Duplex102148787Equine/HorseIn-vitro grade; in-vivo gradeDetail


CD126/IL-6R alpha/IL6R antibody/GMab

Cat No.SpeciesAntibody NameFormatClassified by tagDetail
GM-Tg-hg-TA027-AbHumanAnti-Human CD126/IL-6R alpha/IL6R monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-rg-TA027-AbRatAnti-Rat CD126/IL-6R alpha/IL6R monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-mg-TA027-AbMouseAnti-Mouse CD126/IL-6R alpha/IL6R monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-cynog-TA027-AbCynomolgus/Rhesus macaqueAnti-Cynomolgus/Rhesus macaque CD126/IL-6R alpha/IL6R monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-felg-TA027-AbCat/FelineAnti-Cat/Feline CD126/IL-6R alpha/IL6R monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-cang-TA027-AbDog/CanineAnti-Dog/Canine CD126/IL-6R alpha/IL6R monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-bovg-TA027-AbBovines/CattleAnti-Bovines/Cattle CD126/IL-6R alpha/IL6R monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-equg-TA027-AbEquine/HorseAnti-Equine/Horse CD126/IL-6R alpha/IL6R monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail


CD126/IL-6R alpha/IL6R VLP (virus-like particle)/protein

Cat No.SpeciesAntigen NameExpression PlatformDetail
GM-Tg-hg-TA027-AgHumanHuman CD126/IL-6R alpha/IL6R VLP (virus-like particle)HEK293Products Developing
GM-Tg-rg-TA027-AgRatRat CD126/IL-6R alpha/IL6R VLP (virus-like particle)HEK293Products Developing
GM-Tg-mg-TA027-AgMouseMouse CD126/IL-6R alpha/IL6R VLP (virus-like particle)HEK293Products Developing
GM-Tg-cynog-TA027-AgCynomolgus/Rhesus macaqueCynomolgus/Rhesus macaque CD126/IL-6R alpha/IL6R VLP (virus-like particle)HEK293Products Developing
GM-Tg-felg-TA027-AgCat/FelineCat/Feline CD126/IL-6R alpha/IL6R VLP (virus-like particle)HEK293Products Developing
GM-Tg-cang-TA027-AgDog/CanineDog/Canine CD126/IL-6R alpha/IL6R VLP (virus-like particle)HEK293Products Developing
GM-Tg-bovg-TA027-AgBovines/CattleBovines/Cattle CD126/IL-6R alpha/IL6R VLP (virus-like particle)HEK293Products Developing
GM-Tg-equg-TA027-AgEquine/HorseEquine/Horse CD126/IL-6R alpha/IL6R VLP (virus-like particle)HEK293Products Developing