Explore HLA-DR/HLA-DRA gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes/macrophages, and plays a central role in the immune system and response by presenting peptides derived from extracellular proteins, in particular, pathogen-derived peptides to T cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Aug 2020]
| Target ID |
GM-TA008
|
| Target Name |
HLA-DR/HLA-DRA
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3122
|
| Gene ID |
100051944 (Equus caballus), 100187587 (Macaca mulatta), 294269 (Rattus norvegicus), 3122 (Homo sapiens)
481731 (Canis lupus familiaris), 506214 (Bos taurus)
|
| Target Alternative Names |
BOLA-DRA,DA1,DLA-DRA,DLA-DRA1,DR alpha chain,DR-alpha,DRA,Eqca-DRA,H2-Ea,HLA class II histocompatibility antigen,HLA-DR,HLA-DRA,HLA-DRA1,MAMU-DRA,MHC class II antigen DRA,Mamu-DRA1,RT1-Da,RT1-u,ela-DRA
|
| Uniprot Accession |
Q30631,P01903
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Disease from KEGG |
Phagosome, Cell adhesion molecules, Antigen processing and presentation, Hematopoietic cell lineage, Th1 and Th2 cell differentiation, Th17 cell differentiation, Intestinal immune network for IgA production, Type I diabetes mellitus, Leishmaniasis, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Influenza A, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection, Asthma, Autoimmune thyroid disease, Inflammatory bowel disease, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Viral myocarditis
|
| Gene Ensembl |
ENSECAG00000012660, ENSG00000204287, ENSCAFG00845017467, ENSBTAG00000010645
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
HLA-DR/HLA-DRA siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3122 | Pre-made Human HLA-DRA/HLA-DRA1 siRNA oligo Duplex | 3122 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo294269 | Pre-made Rat RT1-Da/DA1/H2-Ea siRNA oligo Duplex | 294269 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100187587 | Pre-made Cynomolgus/Rhesus macaque MAMU-DRA/DRA/HLA-DRA siRNA oligo Duplex | 100187587 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo481731 | Pre-made Dog/Canine DLA-DRA/DLA-DRA1 siRNA oligo Duplex | 481731 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo506214 | Pre-made Bovines/Cattle BOLA-DRA siRNA oligo Duplex | 506214 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051944 | Pre-made Equine/Horse DRA/ela-DRA/Eqca-DRA siRNA oligo Duplex | 100051944 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
HLA-DR/HLA-DRA antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-TA008-Ab | Human | Anti-Human HLA-DR/HLA-DRA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-TA008-Ab | Rat | Anti-Rat HLA-DR/HLA-DRA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-TA008-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque HLA-DR/HLA-DRA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-TA008-Ab | Dog/Canine | Anti-Dog/Canine HLA-DR/HLA-DRA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-TA008-Ab | Bovines/Cattle | Anti-Bovines/Cattle HLA-DR/HLA-DRA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-TA008-Ab | Equine/Horse | Anti-Equine/Horse HLA-DR/HLA-DRA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
HLA-DR/HLA-DRA VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-TA008-Ag | Human | Human HLA-DR/HLA-DRA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-TA008-Ag | Rat | Rat HLA-DR/HLA-DRA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-TA008-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque HLA-DR/HLA-DRA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-TA008-Ag | Dog/Canine | Dog/Canine HLA-DR/HLA-DRA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-TA008-Ag | Bovines/Cattle | Bovines/Cattle HLA-DR/HLA-DRA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-TA008-Ag | Equine/Horse | Equine/Horse HLA-DR/HLA-DRA VLP (virus-like particle) | HEK293 | Products Developing |
