Explore Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
| Target ID |
GM-T97587
|
| Target Name |
Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3676
|
| Gene ID |
100067886 (Equus caballus), 101081745 (Felis catus), 16401 (Mus musculus), 282882 (Bos taurus)
311144 (Rattus norvegicus), 3676 (Homo sapiens), 488429 (Canis lupus familiaris), 704745 (Macaca mulatta)
|
| Target Alternative Names |
ITGA4,Itga4,CD49D,Itga4B,IA4
|
| Uniprot Accession |
Q00651,P13612
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease |
cancer
|
| Disease from KEGG |
PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, Hematopoietic cell lineage, Leukocyte transendothelial migration, Intestinal immune network for IgA production, Regulation of actin cytoskeleton, Yersinia infection, Leishmaniasis, Human papillomavirus infection, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy
|
| Gene Ensembl |
ENSECAG00000010500, ENSMUSG00000027009, ENSBTAG00000009256, ENSG00000115232, ENSCAFG00845027215, ENSMMUG00000000300
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3676 | Pre-made Human ITGA4/IA4/CD49D siRNA oligo Duplex | 3676 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo311144 | Pre-made Rat Itga4 siRNA oligo Duplex | 311144 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16401 | Pre-made Mouse Itga4/CD49D/Itga4B siRNA oligo Duplex | 16401 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo704745 | Pre-made Cynomolgus/Rhesus macaque ITGA4 siRNA oligo Duplex | 704745 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101081745 | Pre-made Cat/Feline ITGA4 siRNA oligo Duplex | 101081745 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo488429 | Pre-made Dog/Canine ITGA4 siRNA oligo Duplex | 488429 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282882 | Pre-made Bovines/Cattle ITGA4 siRNA oligo Duplex | 282882 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100067886 | Pre-made Equine/Horse ITGA4 siRNA oligo Duplex | 100067886 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T97587-Ab | Human | Anti-Human Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T97587-Ab | Rat | Anti-Rat Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T97587-Ab | Mouse | Anti-Mouse Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T97587-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T97587-Ab | Cat/Feline | Anti-Cat/Feline Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T97587-Ab | Dog/Canine | Anti-Dog/Canine Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T97587-Ab | Bovines/Cattle | Anti-Bovines/Cattle Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T97587-Ab | Equine/Horse | Anti-Equine/Horse Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T97587-Ag | Human | Human Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T97587-Ag | Rat | Rat Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T97587-Ag | Mouse | Mouse Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T97587-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T97587-Ag | Cat/Feline | Cat/Feline Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T97587-Ag | Dog/Canine | Dog/Canine Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T97587-Ag | Bovines/Cattle | Bovines/Cattle Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T97587-Ag | Equine/Horse | Equine/Horse Integrin Alpha 4/Integrin alpha-4/ITGA4/CD49d VLP (virus-like particle) | HEK293 | Products Developing |
