Explore LIFR/CD118 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2018]
| Target ID |
GM-T96894
|
| Target Name |
LIFR/CD118
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3977
|
| Gene ID |
100066903 (Equus caballus), 101097206 (Felis catus), 16880 (Mus musculus), 3977 (Homo sapiens)
449478 (Canis lupus familiaris), 539504 (Bos taurus), 694139 (Macaca mulatta), 81680 (Rattus norvegicus)
|
| Target Alternative Names |
A230075M04Rik,CD118,LIF,LIF receptor,LIF-R,LIFR,Leukemia inhibitory factor receptor,Lifr,SJS2,STWS,SWS
|
| Uniprot Accession |
P42703,P42702,Q5XNR9,O70535
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Signaling pathways regulating pluripotency of stem cells, JAK-STAT signaling pathway
|
| Gene Ensembl |
ENSECAG00000020208, ENSMUSG00000054263, ENSG00000113594, ENSCAFG00845003525, ENSBTAG00000010423, ENSMMUG00000007386
|
| Target Classification |
Tumor-associated antigen (TAA)
|
LIFR/CD118 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3977 | Pre-made Human LIFR/SWS/SJS2 siRNA oligo Duplex | 3977 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo81680 | Pre-made Rat Lifr siRNA oligo Duplex | 81680 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16880 | Pre-made Mouse Lifr/LIF/A230075M04Rik siRNA oligo Duplex | 16880 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo694139 | Pre-made Cynomolgus/Rhesus macaque LIFR siRNA oligo Duplex | 694139 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101097206 | Pre-made Cat/Feline LIFR siRNA oligo Duplex | 101097206 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo449478 | Pre-made Dog/Canine LIFR siRNA oligo Duplex | 449478 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo539504 | Pre-made Bovines/Cattle LIFR siRNA oligo Duplex | 539504 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100066903 | Pre-made Equine/Horse LIFR siRNA oligo Duplex | 100066903 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
LIFR/CD118 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T96894-Ab | Human | Anti-Human LIFR/CD118 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T96894-Ab | Rat | Anti-Rat LIFR/CD118 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T96894-Ab | Mouse | Anti-Mouse LIFR/CD118 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T96894-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque LIFR/CD118 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T96894-Ab | Cat/Feline | Anti-Cat/Feline LIFR/CD118 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T96894-Ab | Dog/Canine | Anti-Dog/Canine LIFR/CD118 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T96894-Ab | Bovines/Cattle | Anti-Bovines/Cattle LIFR/CD118 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T96894-Ab | Equine/Horse | Anti-Equine/Horse LIFR/CD118 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
LIFR/CD118 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T96894-Ag | Human | Human LIFR/CD118 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T96894-Ag | Rat | Rat LIFR/CD118 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T96894-Ag | Mouse | Mouse LIFR/CD118 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T96894-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque LIFR/CD118 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T96894-Ag | Cat/Feline | Cat/Feline LIFR/CD118 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T96894-Ag | Dog/Canine | Dog/Canine LIFR/CD118 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T96894-Ag | Bovines/Cattle | Bovines/Cattle LIFR/CD118 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T96894-Ag | Equine/Horse | Equine/Horse LIFR/CD118 VLP (virus-like particle) | HEK293 | Products Developing |
