Explore GDF5/GDF-5 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mutations in this gene are associated with acromesomelic dysplasia, brachydactyly, chondrodysplasia, multiple synostoses syndrome, proximal symphalangism, and susceptibility to osteoarthritis. [provided by RefSeq, Aug 2016]
| Target ID |
GM-T96760
|
| Target Name |
GDF5/GDF-5
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
8200
|
| Gene ID |
100034228 (Equus caballus), 101081533 (Felis catus), 14563 (Mus musculus), 252835 (Rattus norvegicus)
485850 (Canis lupus familiaris), 539559 (Bos taurus), 705432 (Macaca mulatta), 8200 (Homo sapiens)
|
| Target Alternative Names |
BDA1C,BMP-14,BMP14,Bone morphogenetic protein 14 (BMP-14),CDMP1,Cartilage-derived morphogenetic protein 1 (CDMP-1),Cdmp-1,Cdmp1,DUPANS,GDF-5,GDF5,Gdf5,Growth/differentiation factor 5,LAP-4,LAP4,LPS-associated protein 4),Lipopolysaccharide-associated protein 4 (LAP-4,OS5,Radotermin,SYM1B,SYNS2,bp,brp
|
| Uniprot Accession |
P43027,P43026
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway
|
| Gene Ensembl |
ENSECAG00000019421, ENSMUSG00000038259, ENSCAFG00845019680, ENSBTAG00000004429, ENSMMUG00000057979, ENSG00000125965
|
Pre-made viral vector of GDF5/GDF-5 cDNA Clones/ORF Plasmid
GDF5/GDF-5 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8200 | Pre-made Human GDF5/OS5/LAP4 siRNA oligo Duplex | 8200 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo252835 | Pre-made Rat Gdf5/Cdmp1 siRNA oligo Duplex | 252835 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14563 | Pre-made Mouse Gdf5/bp/brp siRNA oligo Duplex | 14563 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo705432 | Pre-made Cynomolgus/Rhesus macaque GDF5 siRNA oligo Duplex | 705432 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101081533 | Pre-made Cat/Feline GDF5 siRNA oligo Duplex | 101081533 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo485850 | Pre-made Dog/Canine GDF5 siRNA oligo Duplex | 485850 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo539559 | Pre-made Bovines/Cattle GDF5 siRNA oligo Duplex | 539559 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034228 | Pre-made Equine/Horse GDF5 siRNA oligo Duplex | 100034228 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
GDF5/GDF-5 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T96760-Ab | Human | Anti-Human GDF5/GDF-5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T96760-Ab | Rat | Anti-Rat GDF5/GDF-5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T96760-Ab | Mouse | Anti-Mouse GDF5/GDF-5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T96760-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque GDF5/GDF-5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T96760-Ab | Cat/Feline | Anti-Cat/Feline GDF5/GDF-5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T96760-Ab | Dog/Canine | Anti-Dog/Canine GDF5/GDF-5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T96760-Ab | Bovines/Cattle | Anti-Bovines/Cattle GDF5/GDF-5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T96760-Ab | Equine/Horse | Anti-Equine/Horse GDF5/GDF-5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GDF5/GDF-5 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T96760-Ag | Human | Human GDF5/GDF-5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T96760-Ag | Rat | Rat GDF5/GDF-5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T96760-Ag | Mouse | Mouse GDF5/GDF-5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T96760-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque GDF5/GDF-5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T96760-Ag | Cat/Feline | Cat/Feline GDF5/GDF-5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T96760-Ag | Dog/Canine | Dog/Canine GDF5/GDF-5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T96760-Ag | Bovines/Cattle | Bovines/Cattle GDF5/GDF-5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T96760-Ag | Equine/Horse | Equine/Horse GDF5/GDF-5 VLP (virus-like particle) | HEK293 | Products Developing |
