Explore CD11B/Integrin Alpha M/CD11b/ITGAM gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
| Target ID |
GM-T95616
|
| Target Name |
CD11B/Integrin Alpha M/CD11b/ITGAM
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3684
|
| Gene ID |
100064803 (Equus caballus), 101087957 (Felis catus), 16409 (Mus musculus), 25021 (Rattus norvegicus)
3684 (Homo sapiens), 407124 (Bos taurus), 489928 (Canis lupus familiaris), 714832 (Macaca mulatta)
|
| Target Alternative Names |
ITGAM,Itgam,CR3,CR3A,MAC1,Cd11b,Ly-40,Mac-1,Mac-1a,CD11b/CD18,F730045J24Rik,MO1A,CD11B,MAC-1,MAC1A,SLEB6
|
| Uniprot Accession |
P05555,P11215
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Disease from KEGG |
Rap1 signaling pathway, Phagosome, Cell adhesion molecules, Complement and coagulation cascades, Hematopoietic cell lineage, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Pertussis, Legionellosis, Leishmaniasis, Amoebiasis, Staphylococcus aureus infection, Tuberculosis, Acute myeloid leukemia
|
| Gene Ensembl |
ENSECAG00000017418, ENSMUSG00000030786, ENSG00000169896, ENSBTAG00000047238, ENSCAFG00845011550, ENSMMUG00000044324
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
CD11B/Integrin Alpha M/CD11b/ITGAM siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3684 | Pre-made Human ITGAM/CR3A/MO1A siRNA oligo Duplex | 3684 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25021 | Pre-made Rat Itgam/Cd11b siRNA oligo Duplex | 25021 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16409 | Pre-made Mouse Itgam/CR3/CR3A siRNA oligo Duplex | 16409 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo714832 | Pre-made Cynomolgus/Rhesus macaque ITGAM siRNA oligo Duplex | 714832 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101087957 | Pre-made Cat/Feline ITGAM siRNA oligo Duplex | 101087957 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo489928 | Pre-made Dog/Canine ITGAM siRNA oligo Duplex | 489928 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo407124 | Pre-made Bovines/Cattle ITGAM/CD11B siRNA oligo Duplex | 407124 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100064803 | Pre-made Equine/Horse ITGAM siRNA oligo Duplex | 100064803 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CD11B/Integrin Alpha M/CD11b/ITGAM antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T95616-Ab | Human | Anti-Human CD11B/Integrin Alpha M/CD11b/ITGAM monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T95616-Ab | Rat | Anti-Rat CD11B/Integrin Alpha M/CD11b/ITGAM monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T95616-Ab | Mouse | Anti-Mouse CD11B/Integrin Alpha M/CD11b/ITGAM monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T95616-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CD11B/Integrin Alpha M/CD11b/ITGAM monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T95616-Ab | Cat/Feline | Anti-Cat/Feline CD11B/Integrin Alpha M/CD11b/ITGAM monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T95616-Ab | Dog/Canine | Anti-Dog/Canine CD11B/Integrin Alpha M/CD11b/ITGAM monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T95616-Ab | Bovines/Cattle | Anti-Bovines/Cattle CD11B/Integrin Alpha M/CD11b/ITGAM monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T95616-Ab | Equine/Horse | Anti-Equine/Horse CD11B/Integrin Alpha M/CD11b/ITGAM monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CD11B/Integrin Alpha M/CD11b/ITGAM VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T95616-Ag | Human | Human CD11B/Integrin Alpha M/CD11b/ITGAM VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T95616-Ag | Rat | Rat CD11B/Integrin Alpha M/CD11b/ITGAM VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T95616-Ag | Mouse | Mouse CD11B/Integrin Alpha M/CD11b/ITGAM VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T95616-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CD11B/Integrin Alpha M/CD11b/ITGAM VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T95616-Ag | Cat/Feline | Cat/Feline CD11B/Integrin Alpha M/CD11b/ITGAM VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T95616-Ag | Dog/Canine | Dog/Canine CD11B/Integrin Alpha M/CD11b/ITGAM VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T95616-Ag | Bovines/Cattle | Bovines/Cattle CD11B/Integrin Alpha M/CD11b/ITGAM VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T95616-Ag | Equine/Horse | Equine/Horse CD11B/Integrin Alpha M/CD11b/ITGAM VLP (virus-like particle) | HEK293 | Products Developing |
