Explore LDLR/LDL-R gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell. Lysosomes release the cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2022]
| Target ID |
GM-T94692
|
| Target Name |
LDLR/LDL-R
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3949
|
| Gene ID |
100057389 (Equus caballus), 100683160 (Canis lupus familiaris), 101080362 (Felis catus), 16835 (Mus musculus)
281276 (Bos taurus), 300438 (Rattus norvegicus), 3949 (Homo sapiens), 574283 (Macaca mulatta)
|
| Target Alternative Names |
FH,FHC,FHCL1,Hlb301,LDL receptor,LDL-R,LDLCQ2,LDLR,LDLRA,Ldlr,Low-density lipoprotein receptor
|
| Uniprot Accession |
P35951,P01131,P35952,P01130
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Ovarian steroidogenesis, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome, Bile secretion, Cholesterol metabolism, Toxoplasmosis, Hepatitis C, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000019557, ENSCAFG00845021826, ENSMUSG00000032193, ENSBTAG00000012314, ENSG00000130164, ENSMMUG00000003611
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of LDLR/LDL-R cDNA Clones/ORF Plasmid
LDLR/LDL-R siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3949 | Pre-made Human LDLR/FH/FHC siRNA oligo Duplex | 3949 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo300438 | Pre-made Rat Ldlr/LDLRA siRNA oligo Duplex | 300438 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16835 | Pre-made Mouse Ldlr/Hlb301 siRNA oligo Duplex | 16835 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574283 | Pre-made Cynomolgus/Rhesus macaque LDLR siRNA oligo Duplex | 574283 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101080362 | Pre-made Cat/Feline LDLR siRNA oligo Duplex | 101080362 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100683160 | Pre-made Dog/Canine LDLR siRNA oligo Duplex | 100683160 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281276 | Pre-made Bovines/Cattle LDLR siRNA oligo Duplex | 281276 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100057389 | Pre-made Equine/Horse LDLR siRNA oligo Duplex | 100057389 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
LDLR/LDL-R antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T94692-Ab | Human | Anti-Human LDLR/LDL-R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T94692-Ab | Rat | Anti-Rat LDLR/LDL-R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T94692-Ab | Mouse | Anti-Mouse LDLR/LDL-R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T94692-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque LDLR/LDL-R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T94692-Ab | Cat/Feline | Anti-Cat/Feline LDLR/LDL-R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T94692-Ab | Dog/Canine | Anti-Dog/Canine LDLR/LDL-R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T94692-Ab | Bovines/Cattle | Anti-Bovines/Cattle LDLR/LDL-R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T94692-Ab | Equine/Horse | Anti-Equine/Horse LDLR/LDL-R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
LDLR/LDL-R VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T94692-Ag | Human | Human LDLR/LDL-R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T94692-Ag | Rat | Rat LDLR/LDL-R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T94692-Ag | Mouse | Mouse LDLR/LDL-R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T94692-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque LDLR/LDL-R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T94692-Ag | Cat/Feline | Cat/Feline LDLR/LDL-R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T94692-Ag | Dog/Canine | Dog/Canine LDLR/LDL-R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T94692-Ag | Bovines/Cattle | Bovines/Cattle LDLR/LDL-R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T94692-Ag | Equine/Horse | Equine/Horse LDLR/LDL-R VLP (virus-like particle) | HEK293 | Products Developing |
