Explore PTPRJ/CD148/HPTP gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T94449
|
| Target Name |
PTPRJ/CD148/HPTP
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5795
|
| Gene ID |
101086598 (Felis catus), 19271 (Mus musculus), 29645 (Rattus norvegicus), 483617 (Canis lupus familiaris)
508150 (Bos taurus), 5795 (Homo sapiens), 710347 (Macaca mulatta)
|
| Target Alternative Names |
BET,Byp,CD148,DEP-1,DEP1,Density-enhanced phosphatase 1 (DEP-1),HPTP,HPTP eta,HPTPeta,PTPRJ,PTPbeta2,Protein-tyrosine phosphatase eta,Protein-tyrosine phosphatase receptor type J (R-PTP-J),Ptpb2,Ptprj,R-PTP-ETA,R-PTP-J,R-PTP-eta,RPTPJ,Receptor-type tyrosine-protein phosphatase eta,SCC1,Scc-1,Scc1,THC10
|
| Uniprot Accession |
Q64455,Q12913
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Adherens junction
|
| Gene Ensembl |
ENSMUSG00000025314, ENSCAFG00845018509, ENSBTAG00000024715, ENSG00000149177, ENSMMUG00000005861
|
PTPRJ/CD148/HPTP siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5795 | Pre-made Human PTPRJ/DEP1/SCC1 siRNA oligo Duplex | 5795 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29645 | Pre-made Rat Ptprj/DEP-1 siRNA oligo Duplex | 29645 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19271 | Pre-made Mouse Ptprj/BET/Byp siRNA oligo Duplex | 19271 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo710347 | Pre-made Cynomolgus/Rhesus macaque PTPRJ siRNA oligo Duplex | 710347 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101086598 | Pre-made Cat/Feline PTPRJ siRNA oligo Duplex | 101086598 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo483617 | Pre-made Dog/Canine PTPRJ siRNA oligo Duplex | 483617 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo508150 | Pre-made Bovines/Cattle PTPRJ siRNA oligo Duplex | 508150 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
PTPRJ/CD148/HPTP antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T94449-Ab | Human | Anti-Human PTPRJ/CD148/HPTP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T94449-Ab | Rat | Anti-Rat PTPRJ/CD148/HPTP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T94449-Ab | Mouse | Anti-Mouse PTPRJ/CD148/HPTP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T94449-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PTPRJ/CD148/HPTP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T94449-Ab | Cat/Feline | Anti-Cat/Feline PTPRJ/CD148/HPTP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T94449-Ab | Dog/Canine | Anti-Dog/Canine PTPRJ/CD148/HPTP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T94449-Ab | Bovines/Cattle | Anti-Bovines/Cattle PTPRJ/CD148/HPTP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
PTPRJ/CD148/HPTP VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T94449-Ag | Human | Human PTPRJ/CD148/HPTP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T94449-Ag | Rat | Rat PTPRJ/CD148/HPTP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T94449-Ag | Mouse | Mouse PTPRJ/CD148/HPTP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T94449-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PTPRJ/CD148/HPTP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T94449-Ag | Cat/Feline | Cat/Feline PTPRJ/CD148/HPTP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T94449-Ag | Dog/Canine | Dog/Canine PTPRJ/CD148/HPTP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T94449-Ag | Bovines/Cattle | Bovines/Cattle PTPRJ/CD148/HPTP VLP (virus-like particle) | HEK293 | Products Developing |
