Explore NKCC2/SLC12A1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010]
| Target ID |
GM-T93878
|
| Target Name |
NKCC2/SLC12A1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
6557
|
| Gene ID |
100055787 (Equus caballus), 101100216 (Felis catus), 20495 (Mus musculus), 25065 (Rattus norvegicus)
407161 (Bos taurus), 478292 (Canis lupus familiaris), 6557 (Homo sapiens), 714289 (Macaca mulatta)
|
| Target Alternative Names |
BSC,BSC-1,BSC1,Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1 (BSC1),CCC2,D630042G03Rik,Kidney-specific Na-K-Cl symporter,NKCC2,Na-K-2Cl cotransporter 2 (NKCC2),Nkcc2,SLC12A1,Slc12a1,Solute carrier family 12 member 1,mBSC1,mNKCC2,urehr3
|
| Uniprot Accession |
P55014,P55016,Q13621
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
Hyperaldosteronism
|
| Gene Ensembl |
ENSECAG00000038938,ENSECAG00000040429, ENSMUSG00000027202, ENSBTAG00000010145, ENSCAFG00845019364, ENSG00000074803, ENSMMUG00000016896
|
NKCC2/SLC12A1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6557 | Pre-made Human SLC12A1/BSC/BSC1 siRNA oligo Duplex | 6557 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25065 | Pre-made Rat Slc12a1/BSC1/Nkcc2 siRNA oligo Duplex | 25065 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo20495 | Pre-made Mouse Slc12a1/Nkcc2/mBSC1 siRNA oligo Duplex | 20495 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo714289 | Pre-made Cynomolgus/Rhesus macaque SLC12A1 siRNA oligo Duplex | 714289 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100216 | Pre-made Cat/Feline SLC12A1 siRNA oligo Duplex | 101100216 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo478292 | Pre-made Dog/Canine SLC12A1 siRNA oligo Duplex | 478292 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo407161 | Pre-made Bovines/Cattle SLC12A1/BSC1 siRNA oligo Duplex | 407161 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100055787 | Pre-made Equine/Horse SLC12A1 siRNA oligo Duplex | 100055787 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
NKCC2/SLC12A1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T93878-Ab | Human | Anti-Human NKCC2/SLC12A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T93878-Ab | Rat | Anti-Rat NKCC2/SLC12A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T93878-Ab | Mouse | Anti-Mouse NKCC2/SLC12A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T93878-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque NKCC2/SLC12A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T93878-Ab | Cat/Feline | Anti-Cat/Feline NKCC2/SLC12A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T93878-Ab | Dog/Canine | Anti-Dog/Canine NKCC2/SLC12A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T93878-Ab | Bovines/Cattle | Anti-Bovines/Cattle NKCC2/SLC12A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T93878-Ab | Equine/Horse | Anti-Equine/Horse NKCC2/SLC12A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
NKCC2/SLC12A1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T93878-Ag | Human | Human NKCC2/SLC12A1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T93878-Ag | Rat | Rat NKCC2/SLC12A1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T93878-Ag | Mouse | Mouse NKCC2/SLC12A1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T93878-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque NKCC2/SLC12A1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T93878-Ag | Cat/Feline | Cat/Feline NKCC2/SLC12A1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T93878-Ag | Dog/Canine | Dog/Canine NKCC2/SLC12A1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T93878-Ag | Bovines/Cattle | Bovines/Cattle NKCC2/SLC12A1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T93878-Ag | Equine/Horse | Equine/Horse NKCC2/SLC12A1 VLP (virus-like particle) | HEK293 | Products Developing |
