Presenilin/PSEN1 Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore Presenilin/PSEN1 gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Transmembrane Protein.
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]

Pre-made viral vector of Presenilin/PSEN1 cDNA Clones/ORF Plasmid

Presenilin/PSEN1 siRNA/miRNA/oligo for RNA interfence (RNAi)

Presenilin/PSEN1 antibody/GMab

Presenilin/PSEN1 VLP (virus-like particle)/protein