Explore EDNRB gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
| Target ID |
GM-T92828
|
| Target Name |
EDNRB
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1910
|
| Gene ID |
100033875 (Equus caballus), 101086531 (Felis catus), 13618 (Mus musculus), 1910 (Homo sapiens)
281750 (Bos taurus), 403862 (Canis lupus familiaris), 50672 (Rattus norvegicus), 697329 (Macaca mulatta)
|
| Target Alternative Names |
ABCDS,EDNRB,ET-B,ET-BR,ETB,ETB1,ETBR,ETR-b,ETRB,ETb,Ednra,Ednrb,Endothelin receptor non-selective type,Endothelin receptor type B,Etb,HSCR,HSCR2,Sox10m1,WS4A
|
| Uniprot Accession |
O62709,P48302,P24530,P28088,P56497,P21451
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Melanogenesis, Relaxin signaling pathway, Pathways in cancer
|
| Gene Ensembl |
ENSECAG00000024851, ENSMUSG00000022122, ENSG00000136160, ENSBTAG00000005299, ENSCAFG00845027774, ENSMMUG00000005131
|
| Target Classification |
GPCR, Tumor-associated antigen (TAA)
|
Pre-made viral vector of EDNRB cDNA Clones/ORF Plasmid
EDNRB siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1910 | Pre-made Human EDNRB/ETB/ET-B siRNA oligo Duplex | 1910 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo50672 | Pre-made Rat Ednrb/Etb/Ednra siRNA oligo Duplex | 50672 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13618 | Pre-made Mouse Ednrb/ETb/ET-B siRNA oligo Duplex | 13618 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo697329 | Pre-made Cynomolgus/Rhesus macaque EDNRB siRNA oligo Duplex | 697329 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101086531 | Pre-made Cat/Feline EDNRB siRNA oligo Duplex | 101086531 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403862 | Pre-made Dog/Canine EDNRB/ET-B/ET-BR siRNA oligo Duplex | 403862 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281750 | Pre-made Bovines/Cattle EDNRB siRNA oligo Duplex | 281750 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100033875 | Pre-made Equine/Horse EDNRB siRNA oligo Duplex | 100033875 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
EDNRB antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T92828-Ab | Human | Anti-Human EDNRB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T92828-Ab | Rat | Anti-Rat EDNRB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T92828-Ab | Mouse | Anti-Mouse EDNRB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T92828-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque EDNRB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T92828-Ab | Cat/Feline | Anti-Cat/Feline EDNRB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T92828-Ab | Dog/Canine | Anti-Dog/Canine EDNRB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T92828-Ab | Bovines/Cattle | Anti-Bovines/Cattle EDNRB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T92828-Ab | Equine/Horse | Anti-Equine/Horse EDNRB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
EDNRB VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T92828-Ag | Human | Human EDNRB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T92828-Ag | Rat | Rat EDNRB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T92828-Ag | Mouse | Mouse EDNRB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T92828-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque EDNRB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T92828-Ag | Cat/Feline | Cat/Feline EDNRB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T92828-Ag | Dog/Canine | Dog/Canine EDNRB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T92828-Ag | Bovines/Cattle | Bovines/Cattle EDNRB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T92828-Ag | Equine/Horse | Equine/Horse EDNRB VLP (virus-like particle) | HEK293 | Products Developing |
