Explore CD134/OX40/TNFRSF4 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T92124
|
| Target Name |
CD134/OX40/TNFRSF4
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
7293
|
| Gene ID |
100066167 (Equus caballus), 22163 (Mus musculus), 25572 (Rattus norvegicus), 489600 (Canis lupus familiaris)
493665 (Felis catus), 528782 (Bos taurus), 699674 (Macaca mulatta), 7293 (Homo sapiens)
|
| Target Alternative Names |
ACT35,ACT35 antigen,CD134,IMD16,Ly-70,OX40,OX40L receptor,Ox40,TAX transcriptionally-activated glycoprotein 1 receptor,TNFRSF4,TXGP1L,Tnfrsf4,Tumor necrosis factor receptor superfamily member 4,Txgp1
|
| Uniprot Accession |
P47741,P15725,P43489
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction
|
| Gene Ensembl |
ENSECAG00000019948, ENSMUSG00000029075, ENSBTAG00000015635, ENSMMUG00000059937, ENSG00000186827
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of CD134/OX40/TNFRSF4 cDNA Clones/ORF Plasmid
CD134/OX40/TNFRSF4 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7293 | Pre-made Human TNFRSF4/OX40/ACT35 siRNA oligo Duplex | 7293 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25572 | Pre-made Rat Tnfrsf4/Ox40/Txgp1 siRNA oligo Duplex | 25572 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo22163 | Pre-made Mouse Tnfrsf4/Ox40/ACT35 siRNA oligo Duplex | 22163 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo699674 | Pre-made Cynomolgus/Rhesus macaque TNFRSF4 siRNA oligo Duplex | 699674 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493665 | Pre-made Cat/Feline TNFRSF4/OX40/CD134 siRNA oligo Duplex | 493665 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo489600 | Pre-made Dog/Canine TNFRSF4 siRNA oligo Duplex | 489600 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo528782 | Pre-made Bovines/Cattle TNFRSF4 siRNA oligo Duplex | 528782 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100066167 | Pre-made Equine/Horse TNFRSF4 siRNA oligo Duplex | 100066167 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CD134/OX40/TNFRSF4 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T92124-Ab | Human | Anti-Human CD134/OX40/TNFRSF4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T92124-Ab | Rat | Anti-Rat CD134/OX40/TNFRSF4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T92124-Ab | Mouse | Anti-Mouse CD134/OX40/TNFRSF4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T92124-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CD134/OX40/TNFRSF4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T92124-Ab | Cat/Feline | Anti-Cat/Feline CD134/OX40/TNFRSF4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T92124-Ab | Dog/Canine | Anti-Dog/Canine CD134/OX40/TNFRSF4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T92124-Ab | Bovines/Cattle | Anti-Bovines/Cattle CD134/OX40/TNFRSF4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T92124-Ab | Equine/Horse | Anti-Equine/Horse CD134/OX40/TNFRSF4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
CD134/OX40/TNFRSF4 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T92124-Ag | Human | Human CD134/OX40/TNFRSF4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T92124-Ag | Rat | Rat CD134/OX40/TNFRSF4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T92124-Ag | Mouse | Mouse CD134/OX40/TNFRSF4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T92124-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CD134/OX40/TNFRSF4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T92124-Ag | Cat/Feline | Cat/Feline CD134/OX40/TNFRSF4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T92124-Ag | Dog/Canine | Dog/Canine CD134/OX40/TNFRSF4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T92124-Ag | Bovines/Cattle | Bovines/Cattle CD134/OX40/TNFRSF4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T92124-Ag | Equine/Horse | Equine/Horse CD134/OX40/TNFRSF4 VLP (virus-like particle) | HEK293 | Products Developing |
