Explore Fibronectin/FN1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]
| Target ID |
GM-T91696
|
| Target Name |
Fibronectin/FN1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2335
|
| Gene ID |
100034189 (Equus caballus), 101081746 (Felis catus), 14268 (Mus musculus), 2335 (Homo sapiens)
25661 (Rattus norvegicus), 280794 (Bos taurus), 403845 (Canis lupus familiaris), 613269 (Macaca mulatta)
|
| Target Alternative Names |
CIG,Cold-insoluble globulin (CIG),E330027I09,ED-B,FIBNEC,FINC,FN,FN1,FNZ,Fibronectin,Fn,Fn-1,Fn1,GFND,GFND2,LETS,MSF,SMDCF,fn-1
|
| Uniprot Accession |
Q28377,P11276,P02751,P04937,P07589,Q28275
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Diagnostics Biomarker, Immuno-oncology Target, INN Index
|
| Disease |
Dent disease, Alport syndrome, Congenital occlusion of ureteropelvic junction, Diabetes type-2, Diabetic Nephropathy, Malignant neoplasm of bladder, Malignant neoplasm of prostate, Nephrotoxicity, metastatic disease
|
| Disease from KEGG |
PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Regulation of actin cytoskeleton, AGE-RAGE signaling pathway in diabetic complications, Yersinia infection, Amoebiasis, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, Small cell lung cancer
|
| Gene Ensembl |
ENSECAG00000000701, ENSMUSG00000026193, ENSG00000115414, ENSBTAG00000008300, ENSCAFG00845021985, ENSMMUG00000012321
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Fibronectin/FN1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2335 | Pre-made Human FN1/FN/CIG siRNA oligo Duplex | 2335 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25661 | Pre-made Rat Fn1/fn-1/FIBNEC siRNA oligo Duplex | 25661 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14268 | Pre-made Mouse Fn1/Fn/Fn-1 siRNA oligo Duplex | 14268 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo613269 | Pre-made Cynomolgus/Rhesus macaque FN1 siRNA oligo Duplex | 613269 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101081746 | Pre-made Cat/Feline FN1 siRNA oligo Duplex | 101081746 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403845 | Pre-made Dog/Canine FN1/FN siRNA oligo Duplex | 403845 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo280794 | Pre-made Bovines/Cattle FN1/FN siRNA oligo Duplex | 280794 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034189 | Pre-made Equine/Horse FN1/FN siRNA oligo Duplex | 100034189 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Fibronectin/FN1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T91696-Ab | Human | Anti-Human Fibronectin/FN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-rg-T91696-Ab | Rat | Anti-Rat Fibronectin/FN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-mg-T91696-Ab | Mouse | Anti-Mouse Fibronectin/FN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-cynog-T91696-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Fibronectin/FN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-felg-T91696-Ab | Cat/Feline | Anti-Cat/Feline Fibronectin/FN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-cang-T91696-Ab | Dog/Canine | Anti-Dog/Canine Fibronectin/FN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-bovg-T91696-Ab | Bovines/Cattle | Anti-Bovines/Cattle Fibronectin/FN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-equg-T91696-Ab | Equine/Horse | Anti-Equine/Horse Fibronectin/FN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
Fibronectin/FN1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T91696-Ag | Human | Human Fibronectin/FN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T91696-Ag | Rat | Rat Fibronectin/FN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T91696-Ag | Mouse | Mouse Fibronectin/FN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T91696-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Fibronectin/FN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T91696-Ag | Cat/Feline | Cat/Feline Fibronectin/FN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T91696-Ag | Dog/Canine | Dog/Canine Fibronectin/FN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T91696-Ag | Bovines/Cattle | Bovines/Cattle Fibronectin/FN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T91696-Ag | Equine/Horse | Equine/Horse Fibronectin/FN1 VLP (virus-like particle) | HEK293 | Products Developing |
