Explore LRP1/CD91/LRP-1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
| Target ID |
GM-T91130
|
| Target Name |
LRP1/CD91/LRP-1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
4035
|
| Gene ID |
100052936 (Equus caballus), 101090780 (Felis catus), 16971 (Mus musculus), 299858 (Rattus norvegicus)
4035 (Homo sapiens), 481124 (Canis lupus familiaris), 533894 (Bos taurus), 710965 (Macaca mulatta)
|
| Target Alternative Names |
A2MR,A2mr,APOER,APR,Alpha-2-macroglobulin receptor (A2MR),Apolipoprotein E receptor (APOER),CD91,DDH3,IGFBP-3R,IGFBP3R,IGFBP3R1,KPA,LRP,LRP-1,LRP1,LRP1A,Lrp,Lrp1,Prolow-density lipoprotein receptor-related protein 1,TGFBR5,b2b1554Clo
|
| Uniprot Accession |
Q91ZX7,G3V928,Q07954
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Cholesterol metabolism, Alzheimer disease, Malaria
|
| Gene Ensembl |
ENSECAG00000012166, ENSMUSG00000040249, ENSG00000123384, ENSCAFG00845010106, ENSBTAG00000010830, ENSMMUG00000021782
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of LRP1/CD91/LRP-1 cDNA Clones/ORF Plasmid
LRP1/CD91/LRP-1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4035 | Pre-made Human LRP1/APR/KPA siRNA oligo Duplex | 4035 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo299858 | Pre-made Rat Lrp1/LRP-1 siRNA oligo Duplex | 299858 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16971 | Pre-made Mouse Lrp1/Lrp/A2mr siRNA oligo Duplex | 16971 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo710965 | Pre-made Cynomolgus/Rhesus macaque LRP1 siRNA oligo Duplex | 710965 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101090780 | Pre-made Cat/Feline LRP1 siRNA oligo Duplex | 101090780 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo481124 | Pre-made Dog/Canine LRP1 siRNA oligo Duplex | 481124 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo533894 | Pre-made Bovines/Cattle LRP1 siRNA oligo Duplex | 533894 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100052936 | Pre-made Equine/Horse LRP1 siRNA oligo Duplex | 100052936 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
LRP1/CD91/LRP-1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T91130-Ab | Human | Anti-Human LRP1/CD91/LRP-1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T91130-Ab | Rat | Anti-Rat LRP1/CD91/LRP-1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T91130-Ab | Mouse | Anti-Mouse LRP1/CD91/LRP-1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T91130-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque LRP1/CD91/LRP-1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T91130-Ab | Cat/Feline | Anti-Cat/Feline LRP1/CD91/LRP-1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T91130-Ab | Dog/Canine | Anti-Dog/Canine LRP1/CD91/LRP-1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T91130-Ab | Bovines/Cattle | Anti-Bovines/Cattle LRP1/CD91/LRP-1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T91130-Ab | Equine/Horse | Anti-Equine/Horse LRP1/CD91/LRP-1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
LRP1/CD91/LRP-1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T91130-Ag | Human | Human LRP1/CD91/LRP-1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T91130-Ag | Rat | Rat LRP1/CD91/LRP-1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T91130-Ag | Mouse | Mouse LRP1/CD91/LRP-1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T91130-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque LRP1/CD91/LRP-1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T91130-Ag | Cat/Feline | Cat/Feline LRP1/CD91/LRP-1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T91130-Ag | Dog/Canine | Dog/Canine LRP1/CD91/LRP-1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T91130-Ag | Bovines/Cattle | Bovines/Cattle LRP1/CD91/LRP-1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T91130-Ag | Equine/Horse | Equine/Horse LRP1/CD91/LRP-1 VLP (virus-like particle) | HEK293 | Products Developing |
