Explore FGFR4/CD334 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017]
| Target ID |
GM-T90989
|
| Target Name |
FGFR4/CD334
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2264
|
| Gene ID |
100068679 (Equus caballus), 101100864 (Felis catus), 14186 (Mus musculus), 2264 (Homo sapiens)
25114 (Rattus norvegicus), 317696 (Bos taurus), 489095 (Canis lupus familiaris), 698494 (Macaca mulatta)
|
| Target Alternative Names |
CD334,FGFR-4,FGFR4,Fgfr-4,Fgfr4,Fibroblast growth factor receptor 4,JTK2,TKF
|
| Uniprot Accession |
Q03142,P22455,Q498D6
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index, Cytokine Target
|
| Disease |
cancer, Breast Cancer, Ovary Cancer
|
| Disease from KEGG |
MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Pathways in cancer
|
| Gene Ensembl |
ENSECAG00000020869, ENSMUSG00000005320, ENSG00000160867, ENSBTAG00000010543, ENSCAFG00845010987, ENSMMUG00000011033
|
| Target Classification |
Kinase
|
Pre-made viral vector of FGFR4/CD334 cDNA Clones/ORF Plasmid
FGFR4/CD334 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2264 | Pre-made Human FGFR4/TKF/JTK2 siRNA oligo Duplex | 2264 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25114 | Pre-made Rat Fgfr4 siRNA oligo Duplex | 25114 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14186 | Pre-made Mouse Fgfr4/Fgfr-4 siRNA oligo Duplex | 14186 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo698494 | Pre-made Cynomolgus/Rhesus macaque FGFR4 siRNA oligo Duplex | 698494 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100864 | Pre-made Cat/Feline FGFR4 siRNA oligo Duplex | 101100864 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo489095 | Pre-made Dog/Canine FGFR4 siRNA oligo Duplex | 489095 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo317696 | Pre-made Bovines/Cattle FGFR4 siRNA oligo Duplex | 317696 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100068679 | Pre-made Equine/Horse FGFR4 siRNA oligo Duplex | 100068679 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
FGFR4/CD334 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T90989-Ab | Human | Anti-Human FGFR4/CD334 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T90989-Ab | Rat | Anti-Rat FGFR4/CD334 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T90989-Ab | Mouse | Anti-Mouse FGFR4/CD334 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T90989-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque FGFR4/CD334 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T90989-Ab | Cat/Feline | Anti-Cat/Feline FGFR4/CD334 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T90989-Ab | Dog/Canine | Anti-Dog/Canine FGFR4/CD334 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T90989-Ab | Bovines/Cattle | Anti-Bovines/Cattle FGFR4/CD334 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T90989-Ab | Equine/Horse | Anti-Equine/Horse FGFR4/CD334 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
FGFR4/CD334 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T90989-Ag | Human | Human FGFR4/CD334 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T90989-Ag | Rat | Rat FGFR4/CD334 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T90989-Ag | Mouse | Mouse FGFR4/CD334 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T90989-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque FGFR4/CD334 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T90989-Ag | Cat/Feline | Cat/Feline FGFR4/CD334 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T90989-Ag | Dog/Canine | Dog/Canine FGFR4/CD334 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T90989-Ag | Bovines/Cattle | Bovines/Cattle FGFR4/CD334 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T90989-Ag | Equine/Horse | Equine/Horse FGFR4/CD334 VLP (virus-like particle) | HEK293 | Products Developing |
