Explore IL-5RA/IL5RA/CD125 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]
| Target ID |
GM-T90828
|
| Target Name |
IL-5RA/IL5RA/CD125
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3568
|
| Gene ID |
100060212 (Equus caballus), 101099031 (Felis catus), 114103 (Rattus norvegicus), 16192 (Mus musculus) 3568 (Homo sapiens), 476553 (Canis lupus familiaris), 615848 (Bos taurus), 704649 (Macaca mulatta)
|
| Target Alternative Names |
CD125,CDw125,HSIL5R3,IL-5 receptor subunit alpha,IL-5R subunit alpha,IL-5R-alpha,IL-5RA,IL5R,IL5RA,Il5r,Il5ra,Interleukin-5 receptor subunit alpha
|
| Uniprot Accession |
P21183,Q01344
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, Hematopoietic cell lineage, Pathways in cancer
|
| Gene Ensembl |
ENSMUSG00000005364, ENSG00000091181, ENSCAFG00845012603, ENSBTAG00000000273, ENSMMUG00000001849
|
| Target Classification |
Cytokine Receptor
|
Pre-made viral vector of IL-5RA/IL5RA/CD125 cDNA Clones/ORF Plasmid
IL-5RA/IL5RA/CD125 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3568 | Pre-made Human IL5RA/IL5R/CD125 siRNA oligo Duplex | 3568 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo114103 | Pre-made Rat Il5ra siRNA oligo Duplex | 114103 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16192 | Pre-made Mouse Il5ra/Il5r/CD125 siRNA oligo Duplex | 16192 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo704649 | Pre-made Cynomolgus/Rhesus macaque IL5RA siRNA oligo Duplex | 704649 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101099031 | Pre-made Cat/Feline IL5RA siRNA oligo Duplex | 101099031 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo476553 | Pre-made Dog/Canine IL5RA siRNA oligo Duplex | 476553 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo615848 | Pre-made Bovines/Cattle IL5RA siRNA oligo Duplex | 615848 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100060212 | Pre-made Equine/Horse IL5RA siRNA oligo Duplex | 100060212 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IL-5RA/IL5RA/CD125 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T90828-Ab | Human | Anti-Human IL-5RA/IL5RA/CD125 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T90828-Ab | Rat | Anti-Rat IL-5RA/IL5RA/CD125 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T90828-Ab | Mouse | Anti-Mouse IL-5RA/IL5RA/CD125 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T90828-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IL-5RA/IL5RA/CD125 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T90828-Ab | Cat/Feline | Anti-Cat/Feline IL-5RA/IL5RA/CD125 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T90828-Ab | Dog/Canine | Anti-Dog/Canine IL-5RA/IL5RA/CD125 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T90828-Ab | Bovines/Cattle | Anti-Bovines/Cattle IL-5RA/IL5RA/CD125 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T90828-Ab | Equine/Horse | Anti-Equine/Horse IL-5RA/IL5RA/CD125 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
IL-5RA/IL5RA/CD125 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T90828-Ag | Human | Human IL-5RA/IL5RA/CD125 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T90828-Ag | Rat | Rat IL-5RA/IL5RA/CD125 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T90828-Ag | Mouse | Mouse IL-5RA/IL5RA/CD125 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T90828-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IL-5RA/IL5RA/CD125 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T90828-Ag | Cat/Feline | Cat/Feline IL-5RA/IL5RA/CD125 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T90828-Ag | Dog/Canine | Dog/Canine IL-5RA/IL5RA/CD125 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T90828-Ag | Bovines/Cattle | Bovines/Cattle IL-5RA/IL5RA/CD125 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T90828-Ag | Equine/Horse | Equine/Horse IL-5RA/IL5RA/CD125 VLP (virus-like particle) | HEK293 | Products Developing |