Explore CCR2a/CCR2/CD192 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3. [provided by RefSeq, Aug 2017]
| Target ID |
GM-T89988
|
| Target Name |
CCR2a/CCR2/CD192
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
729230
|
| Gene ID |
12772 (Mus musculus), 574098 (Macaca mulatta), 60463 (Rattus norvegicus), 729230 (Homo sapiens)
|
| Target Alternative Names |
C-C CKR-2,C-C chemokine receptor type 2,CC-CKR-2,CCR-2,CCR2,CCR2A,CCR2B,CCR2a,CD192,CKR2,CKR2A,CKR2B,CMKBR2,Cc-ckr-2,Ccr2,Ccr2a,Ccr2b,Ckr2,Ckr2a,Ckr2b,Cmkbr2,MCP-1-R,Monocyte chemoattractant protein 1 receptor (MCP-1-R),PCLUD,mJe-r
|
| Uniprot Accession |
P51683,O18793,O55193,P41597
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway
|
| Gene Ensembl |
ENSMUSG00000049103, ENSMMUG00000062394, ENSG00000121807
|
| Target Classification |
GPCR, Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of CCR2a/CCR2/CD192 cDNA Clones/ORF Plasmid
CCR2a/CCR2/CD192 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo729230 | Pre-made Human CCR2/CKR2/CCR-2 siRNA oligo Duplex | 729230 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo60463 | Pre-made Rat Ccr2 siRNA oligo Duplex | 60463 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12772 | Pre-made Mouse Ccr2/Ckr2/Ccr2a siRNA oligo Duplex | 12772 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574098 | Pre-made Cynomolgus/Rhesus macaque CCR2/CCR2B siRNA oligo Duplex | 574098 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
CCR2a/CCR2/CD192 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T89988-Ab | Human | Anti-Human CCR2a/CCR2/CD192 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T89988-Ab | Rat | Anti-Rat CCR2a/CCR2/CD192 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T89988-Ab | Mouse | Anti-Mouse CCR2a/CCR2/CD192 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T89988-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CCR2a/CCR2/CD192 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
CCR2a/CCR2/CD192 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T89988-Ag | Human | Human CCR2a/CCR2/CD192 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T89988-Ag | Rat | Rat CCR2a/CCR2/CD192 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T89988-Ag | Mouse | Mouse CCR2a/CCR2/CD192 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T89988-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CCR2a/CCR2/CD192 VLP (virus-like particle) | HEK293 | Products Developing |
