Explore IDO1 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
| Target ID |
GM-T89697
|
| Target Name |
IDO1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3620
|
| Gene ID |
101096977 (Felis catus), 106782641 (Equus caballus), 15930 (Mus musculus), 3620 (Homo sapiens) 475574 (Canis lupus familiaris), 506281 (Bos taurus), 574370 (Macaca mulatta), 66029 (Rattus norvegicus)
|
| Target Alternative Names |
3-dioxygenase,3-dioxygenase 1,IDO,IDO-1,IDO1,INDO,Ido,Ido1,Indo,Indoleamine 2,Indoleamine-pyrrole 2
|
| Uniprot Accession |
P28776,P14902,Q9ERD9
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Disease from KEGG |
Metabolic pathways, African trypanosomiasis
|
| Gene Ensembl |
ENSECAG00000022118, ENSMUSG00000031551, ENSG00000131203, ENSCAFG00845009259, ENSBTAG00000020602, ENSMMUG00000019304
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of IDO1 cDNA Clones/ORF Plasmid
IDO1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3620 | Pre-made Human IDO1/IDO/INDO siRNA oligo Duplex | 3620 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo66029 | Pre-made Rat Ido1/Ido/Indo siRNA oligo Duplex | 66029 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo15930 | Pre-made Mouse Ido1/Ido/Indo siRNA oligo Duplex | 15930 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574370 | Pre-made Cynomolgus/Rhesus macaque IDO1/INDO siRNA oligo Duplex | 574370 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101096977 | Pre-made Cat/Feline IDO1 siRNA oligo Duplex | 101096977 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo475574 | Pre-made Dog/Canine IDO1/INDO siRNA oligo Duplex | 475574 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo506281 | Pre-made Bovines/Cattle IDO1/INDO siRNA oligo Duplex | 506281 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo106782641 | Pre-made Equine/Horse IDO1 siRNA oligo Duplex | 106782641 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IDO1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T89697-Ab | Human | Anti-Human IDO1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T89697-Ab | Rat | Anti-Rat IDO1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T89697-Ab | Mouse | Anti-Mouse IDO1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T89697-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IDO1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T89697-Ab | Cat/Feline | Anti-Cat/Feline IDO1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T89697-Ab | Dog/Canine | Anti-Dog/Canine IDO1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T89697-Ab | Bovines/Cattle | Anti-Bovines/Cattle IDO1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T89697-Ab | Equine/Horse | Anti-Equine/Horse IDO1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
IDO1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T89697-Ag | Human | Human IDO1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T89697-Ag | Rat | Rat IDO1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T89697-Ag | Mouse | Mouse IDO1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T89697-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IDO1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T89697-Ag | Cat/Feline | Cat/Feline IDO1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T89697-Ag | Dog/Canine | Dog/Canine IDO1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T89697-Ag | Bovines/Cattle | Bovines/Cattle IDO1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T89697-Ag | Equine/Horse | Equine/Horse IDO1 recombinant protein | Mammalian cell | Detail |