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Target
sublocation: Introcelluar Protein.
Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T88729
|
| Target Name |
UCP1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
7350
|
| Gene ID |
100063105 (Equus caballus), 101089511 (Felis catus), 22227 (Mus musculus), 24860 (Rattus norvegicus) 281561 (Bos taurus), 403574 (Canis lupus familiaris), 574124 (Macaca mulatta), 7350 (Homo sapiens)
|
| Target Alternative Names |
Mitochondrial brown fat uncoupling protein 1,SLC25A7,Slc25a7,Solute carrier family 25 member 7,Thermogenin,UCP,UCP 1,UCP1,Ucp,Ucp1,Ucpa,Uncp
|
| Uniprot Accession |
P12242,P04633,P10861,Q9GMZ1,P25874
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
PPAR signaling pathway
|
| Gene Ensembl |
ENSECAG00000026962, ENSMUSG00000031710, ENSBTAG00000004647, ENSCAFG00845020627, ENSMMUG00000015244, ENSG00000109424
|
Pre-made viral vector of UCP1 cDNA Clones/ORF Plasmid
UCP1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7350 | Pre-made Human UCP1/UCP/SLC25A7 siRNA oligo Duplex | 7350 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24860 | Pre-made Rat Ucp1/Ucp/Ucpa siRNA oligo Duplex | 24860 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo22227 | Pre-made Mouse Ucp1/Ucp/Slc25a7 siRNA oligo Duplex | 22227 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574124 | Pre-made Cynomolgus/Rhesus macaque UCP1 siRNA oligo Duplex | 574124 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101089511 | Pre-made Cat/Feline UCP1 siRNA oligo Duplex | 101089511 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403574 | Pre-made Dog/Canine UCP1 siRNA oligo Duplex | 403574 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281561 | Pre-made Bovines/Cattle UCP1 siRNA oligo Duplex | 281561 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100063105 | Pre-made Equine/Horse UCP1 siRNA oligo Duplex | 100063105 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
UCP1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T88729-Ab | Human | Anti-Human UCP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T88729-Ab | Rat | Anti-Rat UCP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T88729-Ab | Mouse | Anti-Mouse UCP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T88729-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque UCP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T88729-Ab | Cat/Feline | Anti-Cat/Feline UCP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T88729-Ab | Dog/Canine | Anti-Dog/Canine UCP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T88729-Ab | Bovines/Cattle | Anti-Bovines/Cattle UCP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T88729-Ab | Equine/Horse | Anti-Equine/Horse UCP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
UCP1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T88729-Ag | Human | Human UCP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T88729-Ag | Rat | Rat UCP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T88729-Ag | Mouse | Mouse UCP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T88729-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque UCP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T88729-Ag | Cat/Feline | Cat/Feline UCP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T88729-Ag | Dog/Canine | Dog/Canine UCP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T88729-Ag | Bovines/Cattle | Bovines/Cattle UCP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T88729-Ag | Equine/Horse | Equine/Horse UCP1 recombinant protein | Mammalian cell | Detail |