Explore DNMT1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
| Target ID |
GM-T88304
|
| Target Name |
DNMT1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1786
|
| Gene ID |
100058341 (Equus caballus), 101093502 (Felis catus), 13433 (Mus musculus), 1786 (Homo sapiens)
281119 (Bos taurus), 476715 (Canis lupus familiaris), 574321 (Macaca mulatta), 84350 (Rattus norvegicus)
|
| Target Alternative Names |
ADCADN,AIM,CXXC-type zinc finger protein 9,CXXC9,Cxxc9,DNA (cytosine-5)-methyltransferase 1,DNA methyltransferase HsaI (DNA MTase HsaI,DNMT,DNMT1,Dnmt,Dnmt1,Dnmt1o,HSN1E,M.HsaI),MCMT,MTase,Met-1,Met1,MommeD2,m.HsaI,m.MmuI
|
| Uniprot Accession |
P13864,P26358,Q24K09,Q9Z330
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Metabolic pathways
|
| Gene Ensembl |
ENSECAG00000026909, ENSMUSG00000004099, ENSG00000130816, ENSBTAG00000002736, ENSCAFG00845018246, ENSMMUG00000014604
|
| Target Classification |
Epigenetic, Tumor-associated antigen (TAA)
|
Pre-made viral vector of DNMT1 cDNA Clones/ORF Plasmid
DNMT1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1786 | Pre-made Human DNMT1/AIM/DNMT siRNA oligo Duplex | 1786 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo84350 | Pre-made Rat Dnmt1 siRNA oligo Duplex | 84350 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13433 | Pre-made Mouse Dnmt1/Dnmt/MCMT siRNA oligo Duplex | 13433 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574321 | Pre-made Cynomolgus/Rhesus macaque DNMT1 siRNA oligo Duplex | 574321 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101093502 | Pre-made Cat/Feline DNMT1 siRNA oligo Duplex | 101093502 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo476715 | Pre-made Dog/Canine DNMT1 siRNA oligo Duplex | 476715 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281119 | Pre-made Bovines/Cattle DNMT1/DNMT siRNA oligo Duplex | 281119 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100058341 | Pre-made Equine/Horse DNMT1 siRNA oligo Duplex | 100058341 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
DNMT1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T88304-Ab | Human | Anti-Human DNMT1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T88304-Ab | Rat | Anti-Rat DNMT1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T88304-Ab | Mouse | Anti-Mouse DNMT1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T88304-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque DNMT1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T88304-Ab | Cat/Feline | Anti-Cat/Feline DNMT1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T88304-Ab | Dog/Canine | Anti-Dog/Canine DNMT1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T88304-Ab | Bovines/Cattle | Anti-Bovines/Cattle DNMT1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T88304-Ab | Equine/Horse | Anti-Equine/Horse DNMT1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
DNMT1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T88304-Ag | Human | Human DNMT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T88304-Ag | Rat | Rat DNMT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T88304-Ag | Mouse | Mouse DNMT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T88304-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque DNMT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T88304-Ag | Cat/Feline | Cat/Feline DNMT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T88304-Ag | Dog/Canine | Dog/Canine DNMT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T88304-Ag | Bovines/Cattle | Bovines/Cattle DNMT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T88304-Ag | Equine/Horse | Equine/Horse DNMT1 recombinant protein | Mammalian cell | Detail |
