Explore Mesothelin/MSLN gene products and cross-species
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biological information, expression tools, and therapeutic
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Target
sublocation: Transmembrane Protein.
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
| Target ID |
GM-T87108
|
| Target Name |
Mesothelin/MSLN
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
10232
|
| Gene ID |
10232 (Homo sapiens), 516237 (Bos taurus), 56047 (Mus musculus), 698095 (Macaca mulatta)
|
| Target Alternative Names |
CAK1 antigen,MPF,MSLN,Mesothelin,Msln,Pre-pro-megakaryocyte-potentiating factor,SMRP
|
| Uniprot Accession |
Q13421,Q61468
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease |
cancer, Breast Cancer, human tumors, Malignant neoplasm of bladder
|
| Gene Ensembl |
ENSG00000102854, ENSBTAG00000000177, ENSMUSG00000063011, ENSMMUG00000000835
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of Mesothelin/MSLN cDNA Clones/ORF Plasmid
Mesothelin/MSLN siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo10232 | Pre-made Human MSLN/MPF/SMRP siRNA oligo Duplex | 10232 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo56047 | Pre-made Mouse Msln/MPF siRNA oligo Duplex | 56047 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo698095 | Pre-made Cynomolgus/Rhesus macaque MSLN siRNA oligo Duplex | 698095 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo516237 | Pre-made Bovines/Cattle MSLN siRNA oligo Duplex | 516237 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
Mesothelin/MSLN antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T87108-Ab | Human | Anti-Human Mesothelin/MSLN monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T87108-Ab | Mouse | Anti-Mouse Mesothelin/MSLN monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T87108-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Mesothelin/MSLN monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T87108-Ab | Bovines/Cattle | Anti-Bovines/Cattle Mesothelin/MSLN monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Mesothelin/MSLN VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T87108-Ag | Human | Human Mesothelin/MSLN VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T87108-Ag | Mouse | Mouse Mesothelin/MSLN VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T87108-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Mesothelin/MSLN VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T87108-Ag | Bovines/Cattle | Bovines/Cattle Mesothelin/MSLN VLP (virus-like particle) | HEK293 | Products Developing |
