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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008]
| Target ID |
GM-T86731
|
| Target Name |
ATP1A1/ATP1A2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
477
|
| Gene ID |
477 (Homo sapiens), 720191 (Macaca mulatta)
|
| Target Alternative Names |
ATP1A1,ATP1A2,DEE98,FARIMPD,FHM2,MHP2,Na(+)/K(+) ATPase alpha-2 subunit,Sodium pump subunit alpha-2,Sodium/potassium-transporting ATPase subunit alpha-2
|
| Uniprot Accession |
P50993
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
cGMP-PKG signaling pathway, cAMP signaling pathway, Adrenergic signaling in cardiomyocytes, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption
|
| Gene Ensembl |
ENSG00000018625, ENSMMUG00000017833
|
ATP1A1/ATP1A2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo477 | Pre-made Human ATP1A2/FHM2/MHP2 siRNA oligo Duplex | 477 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo720191 | Pre-made Cynomolgus/Rhesus macaque ATP1A2 siRNA oligo Duplex | 720191 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
ATP1A1/ATP1A2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T86731-Ab | Human | Anti-Human ATP1A1/ATP1A2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T86731-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ATP1A1/ATP1A2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
ATP1A1/ATP1A2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T86731-Ag | Human | Human ATP1A1/ATP1A2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T86731-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ATP1A1/ATP1A2 VLP (virus-like particle) | HEK293 | Products Developing |
