Explore GPBAR1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T86273
|
| Target Name |
GPBAR1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
151306
|
| Gene ID |
100055590 (Equus caballus), 101089457 (Felis catus), 151306 (Homo sapiens), 227289 (Mus musculus)
317756 (Bos taurus), 338443 (Rattus norvegicus), 488521 (Canis lupus familiaris), 697937 (Macaca mulatta)
|
| Target Alternative Names |
GPBAR1,Gpbar1,BG37,TGR5,M-BAR,GPCR19,GPR131,GPCR,Tgr5
|
| Uniprot Accession |
Q8TDU6,Q80SS6,Q862A9,Q80T02
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
|
| Disease from KEGG |
|
| Gene Ensembl |
ENSECAG00000006763, ENSG00000179921, ENSMUSG00000064272, ENSBTAG00000003923, ENSCAFG00845026665, ENSMMUG00000065075
|
| Target Classification |
GPCR
|
Pre-made viral vector of GPBAR1 cDNA Clones/ORF Plasmid
GPBAR1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo151306 | Pre-made Human GPBAR1/BG37/TGR5 siRNA oligo Duplex | 151306 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo338443 | Pre-made Rat Gpbar1/Tgr5/M-BAR siRNA oligo Duplex | 338443 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo227289 | Pre-made Mouse Gpbar1/BG37/GPCR siRNA oligo Duplex | 227289 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo697937 | Pre-made Cynomolgus/Rhesus macaque GPBAR1 siRNA oligo Duplex | 697937 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101089457 | Pre-made Cat/Feline GPBAR1 siRNA oligo Duplex | 101089457 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo488521 | Pre-made Dog/Canine GPBAR1 siRNA oligo Duplex | 488521 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo317756 | Pre-made Bovines/Cattle GPBAR1/TGR5 siRNA oligo Duplex | 317756 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100055590 | Pre-made Equine/Horse GPBAR1 siRNA oligo Duplex | 100055590 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
GPBAR1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T86273-Ab | Human | Anti-Human GPBAR1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T86273-Ab | Rat | Anti-Rat GPBAR1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T86273-Ab | Mouse | Anti-Mouse GPBAR1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T86273-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque GPBAR1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T86273-Ab | Cat/Feline | Anti-Cat/Feline GPBAR1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T86273-Ab | Dog/Canine | Anti-Dog/Canine GPBAR1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T86273-Ab | Bovines/Cattle | Anti-Bovines/Cattle GPBAR1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T86273-Ab | Equine/Horse | Anti-Equine/Horse GPBAR1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GPBAR1 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T86273-Ag | Human | Human GPBAR1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T86273-Ag | Rat | Rat GPBAR1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T86273-Ag | Mouse | Mouse GPBAR1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T86273-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque GPBAR1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T86273-Ag | Cat/Feline | Cat/Feline GPBAR1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T86273-Ag | Dog/Canine | Dog/Canine GPBAR1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T86273-Ag | Bovines/Cattle | Bovines/Cattle GPBAR1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T86273-Ag | Equine/Horse | Equine/Horse GPBAR1 VLP (virus-like particle) | HEK293 | Products Developing |
