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Target
sublocation: Transmembrane Protein.
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
| Target ID |
GM-T86271
|
| Target Name |
KCNN2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3781
|
| Gene ID |
100064342 (Equus caballus), 101099926 (Felis catus), 140492 (Mus musculus), 3781 (Homo sapiens) 404177 (Bos taurus), 474640 (Canis lupus familiaris), 54262 (Rattus norvegicus), 695374 (Macaca mulatta)
|
| Target Alternative Names |
DYT34,KCNN2,KCa2.2,Kcnn2,NEDMAB,SK2,SKCA2,SKCa 2,SKCa2,Small conductance calcium-activated potassium channel protein 2,bc,fri,hSK2
|
| Uniprot Accession |
P58390,Q9H2S1,P70604
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Serotonergic synapse, Insulin secretion, GnRH secretion, Bile secretion
|
| Gene Ensembl |
ENSECAG00000020082, ENSMUSG00000054477, ENSG00000080709, ENSBTAG00000011076, ENSCAFG00845010795, ENSMMUG00000020502
|
Pre-made viral vector of KCNN2 cDNA Clones/ORF Plasmid
KCNN2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3781 | Pre-made Human KCNN2/SK2/hSK2 siRNA oligo Duplex | 3781 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo54262 | Pre-made Rat Kcnn2/SK2/SKCa2 siRNA oligo Duplex | 54262 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo140492 | Pre-made Mouse Kcnn2/bc/SK2 siRNA oligo Duplex | 140492 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo695374 | Pre-made Cynomolgus/Rhesus macaque KCNN2 siRNA oligo Duplex | 695374 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101099926 | Pre-made Cat/Feline KCNN2 siRNA oligo Duplex | 101099926 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo474640 | Pre-made Dog/Canine KCNN2 siRNA oligo Duplex | 474640 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo404177 | Pre-made Bovines/Cattle KCNN2/SK2 siRNA oligo Duplex | 404177 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100064342 | Pre-made Equine/Horse KCNN2 siRNA oligo Duplex | 100064342 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
KCNN2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T86271-Ab | Human | Anti-Human KCNN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T86271-Ab | Rat | Anti-Rat KCNN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T86271-Ab | Mouse | Anti-Mouse KCNN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T86271-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque KCNN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T86271-Ab | Cat/Feline | Anti-Cat/Feline KCNN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T86271-Ab | Dog/Canine | Anti-Dog/Canine KCNN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T86271-Ab | Bovines/Cattle | Anti-Bovines/Cattle KCNN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T86271-Ab | Equine/Horse | Anti-Equine/Horse KCNN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
KCNN2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T86271-Ag | Human | Human KCNN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T86271-Ag | Rat | Rat KCNN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T86271-Ag | Mouse | Mouse KCNN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T86271-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque KCNN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T86271-Ag | Cat/Feline | Cat/Feline KCNN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T86271-Ag | Dog/Canine | Dog/Canine KCNN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T86271-Ag | Bovines/Cattle | Bovines/Cattle KCNN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T86271-Ag | Equine/Horse | Equine/Horse KCNN2 VLP (virus-like particle) | HEK293 | Products Developing |