Explore LRP5 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
| Target ID |
GM-T86072
|
| Target Name |
LRP5
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
4041
|
| Gene ID |
100147353 (Equus caballus), 100306933 (Canis lupus familiaris), 101084481 (Felis catus), 16973 (Mus musculus)
293649 (Rattus norvegicus), 4041 (Homo sapiens), 534450 (Bos taurus), 721605 (Macaca mulatta)
|
| Target Alternative Names |
BMND1,EVR1,EVR4,HBM,LR3,LRP-5,LRP-7,LRP5,LRP5L,LRP7,Low-density lipoprotein receptor-related protein 5,Low-density lipoprotein receptor-related protein 7 (LRP-7),Lrp5,OPPG,OPS,OPTA1,PCLD4,VBCH2,mKIAA4142
|
| Uniprot Accession |
Q91VN0,O75197
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Wnt signaling pathway, Parathyroid hormone synthesis, secretion and action, Alzheimer disease, Pathways in cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer
|
| Gene Ensembl |
ENSECAG00000013180, ENSCAFG00845007778, ENSMUSG00000024913, ENSG00000162337, ENSBTAG00000005903, ENSMMUG00000031237
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of LRP5 cDNA Clones/ORF Plasmid
LRP5 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4041 | Pre-made Human LRP5/HBM/LR3 siRNA oligo Duplex | 4041 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo293649 | Pre-made Rat Lrp5 siRNA oligo Duplex | 293649 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16973 | Pre-made Mouse Lrp5/HBM/LR3 siRNA oligo Duplex | 16973 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo721605 | Pre-made Cynomolgus/Rhesus macaque LRP5 siRNA oligo Duplex | 721605 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101084481 | Pre-made Cat/Feline LRP5 siRNA oligo Duplex | 101084481 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100306933 | Pre-made Dog/Canine LRP5 siRNA oligo Duplex | 100306933 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo534450 | Pre-made Bovines/Cattle LRP5/LRP5L siRNA oligo Duplex | 534450 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100147353 | Pre-made Equine/Horse LRP5 siRNA oligo Duplex | 100147353 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
LRP5 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T86072-Ab | Human | Anti-Human LRP5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T86072-Ab | Rat | Anti-Rat LRP5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T86072-Ab | Mouse | Anti-Mouse LRP5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T86072-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque LRP5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T86072-Ab | Cat/Feline | Anti-Cat/Feline LRP5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T86072-Ab | Dog/Canine | Anti-Dog/Canine LRP5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T86072-Ab | Bovines/Cattle | Anti-Bovines/Cattle LRP5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T86072-Ab | Equine/Horse | Anti-Equine/Horse LRP5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
LRP5 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T86072-Ag | Human | Human LRP5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T86072-Ag | Rat | Rat LRP5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T86072-Ag | Mouse | Mouse LRP5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T86072-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque LRP5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T86072-Ag | Cat/Feline | Cat/Feline LRP5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T86072-Ag | Dog/Canine | Dog/Canine LRP5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T86072-Ag | Bovines/Cattle | Bovines/Cattle LRP5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T86072-Ag | Equine/Horse | Equine/Horse LRP5 VLP (virus-like particle) | HEK293 | Products Developing |
