Explore SPHK1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]
| Target ID |
GM-T86014
|
| Target Name |
SPHK1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
8877
|
| Gene ID |
100058875 (Equus caballus), 101084918 (Felis catus), 170897 (Rattus norvegicus), 20698 (Mus musculus)
483329 (Canis lupus familiaris), 618605 (Bos taurus), 710441 (Macaca mulatta), 8877 (Homo sapiens)
|
| Target Alternative Names |
1110006G24Rik,Acetyltransferase SPHK1,SK 1,SPHK,SPHK1,SPK 1,Sk1,Sphingosine kinase 1,Sphk1,Spk1
|
| Uniprot Accession |
Q91V26,Q8CI15,Q9NYA1
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Metabolic pathways, Calcium signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Tuberculosis, Sphingolipid metabolism
|
| Gene Ensembl |
ENSECAG00000023642, ENSMUSG00000061878, ENSBTAG00000008507, ENSMMUG00000018011, ENSG00000176170
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of SPHK1 cDNA Clones/ORF Plasmid
SPHK1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8877 | Pre-made Human SPHK1/SPHK siRNA oligo Duplex | 8877 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo170897 | Pre-made Rat Sphk1 siRNA oligo Duplex | 170897 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo20698 | Pre-made Mouse Sphk1/Sk1/Spk1 siRNA oligo Duplex | 20698 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo710441 | Pre-made Cynomolgus/Rhesus macaque SPHK1 siRNA oligo Duplex | 710441 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101084918 | Pre-made Cat/Feline SPHK1 siRNA oligo Duplex | 101084918 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo483329 | Pre-made Dog/Canine SPHK1 siRNA oligo Duplex | 483329 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo618605 | Pre-made Bovines/Cattle SPHK1 siRNA oligo Duplex | 618605 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100058875 | Pre-made Equine/Horse SPHK1 siRNA oligo Duplex | 100058875 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
SPHK1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T86014-Ab | Human | Anti-Human SPHK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T86014-Ab | Rat | Anti-Rat SPHK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T86014-Ab | Mouse | Anti-Mouse SPHK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T86014-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SPHK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T86014-Ab | Cat/Feline | Anti-Cat/Feline SPHK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T86014-Ab | Dog/Canine | Anti-Dog/Canine SPHK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T86014-Ab | Bovines/Cattle | Anti-Bovines/Cattle SPHK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T86014-Ab | Equine/Horse | Anti-Equine/Horse SPHK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
SPHK1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T86014-Ag | Human | Human SPHK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T86014-Ag | Rat | Rat SPHK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T86014-Ag | Mouse | Mouse SPHK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T86014-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SPHK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T86014-Ag | Cat/Feline | Cat/Feline SPHK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T86014-Ag | Dog/Canine | Dog/Canine SPHK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T86014-Ag | Bovines/Cattle | Bovines/Cattle SPHK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T86014-Ag | Equine/Horse | Equine/Horse SPHK1 VLP (virus-like particle) | HEK293 | Products Developing |
