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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. In addition, the shorter (predominant) isoform is an antimicrobial protein, displaying antibacterial and antifungal activity against B. cereus, E. coli, E. faecalis, S. mitis, S. epidermidis, and C. albicans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020]
| Target ID |
GM-T85857
|
| Target Name |
TSLP
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
85480
|
| Gene ID |
100302635 (Equus caballus), 101085857 (Felis catus), 53603 (Mus musculus), 607671 (Canis lupus familiaris) 617637 (Bos taurus), 688621 (Rattus norvegicus), 706194 (Macaca mulatta), 85480 (Homo sapiens)
|
| Target Alternative Names |
TSLP,Thymic stromal lymphopoietin,Tslp
|
| Uniprot Accession |
Q9JIE6,Q969D9
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, INN Index
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway
|
| Gene Ensembl |
ENSECAG00000022141, ENSMUSG00000024379, ENSBTAG00000060087, ENSG00000145777
|
| Target Classification |
Cytokine Receptor
|
Pre-made viral vector of TSLP cDNA Clones/ORF Plasmid
TSLP siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo85480 | Pre-made Human TSLP siRNA oligo Duplex | 85480 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo688621 | Pre-made Rat Tslp siRNA oligo Duplex | 688621 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo53603 | Pre-made Mouse Tslp siRNA oligo Duplex | 53603 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo706194 | Pre-made Cynomolgus/Rhesus macaque TSLP siRNA oligo Duplex | 706194 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101085857 | Pre-made Cat/Feline TSLP siRNA oligo Duplex | 101085857 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo607671 | Pre-made Dog/Canine TSLP siRNA oligo Duplex | 607671 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo617637 | Pre-made Bovines/Cattle TSLP siRNA oligo Duplex | 617637 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100302635 | Pre-made Equine/Horse TSLP siRNA oligo Duplex | 100302635 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TSLP antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T85857-Ab | Human | Anti-Human TSLP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T85857-Ab | Rat | Anti-Rat TSLP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T85857-Ab | Mouse | Anti-Mouse TSLP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T85857-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TSLP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T85857-Ab | Cat/Feline | Anti-Cat/Feline TSLP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T85857-Ab | Dog/Canine | Anti-Dog/Canine TSLP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T85857-Ab | Bovines/Cattle | Anti-Bovines/Cattle TSLP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T85857-Ab | Equine/Horse | Anti-Equine/Horse TSLP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
TSLP recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T85857-Ag | Human | Human TSLP recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T85857-Ag | Rat | Rat TSLP recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T85857-Ag | Mouse | Mouse TSLP recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T85857-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TSLP recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T85857-Ag | Cat/Feline | Cat/Feline TSLP recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T85857-Ag | Dog/Canine | Dog/Canine TSLP recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T85857-Ag | Bovines/Cattle | Bovines/Cattle TSLP recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T85857-Ag | Equine/Horse | Equine/Horse TSLP recombinant protein | Mammalian cell | Detail |