Explore CD27 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T85554
|
| Target Name |
CD27
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
939
|
| Gene ID |
100630357 (Equus caballus), 101091633 (Felis catus), 21940 (Mus musculus), 500318 (Rattus norvegicus)
512514 (Bos taurus), 611674 (Canis lupus familiaris), 939 (Homo sapiens)
|
| Target Alternative Names |
CD27,CD27 antigen,CD27L receptor,Cd27,S152,S152. LPFS2,T-cell activation antigen CD27,T14,TNFRSF7,Tnfrsf7,Tp55,Tumor necrosis factor receptor superfamily member 7
|
| Uniprot Accession |
P41272,P26842
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease |
cancer, Dent disease
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction
|
| Gene Ensembl |
ENSECAG00000011126, ENSMUSG00000030336, ENSBTAG00000014725, ENSCAFG00845029234, ENSG00000139193
|
| Target Classification |
Pathway, Checkpoint-Immuno Oncology
|
Pre-made viral vector of CD27 cDNA Clones/ORF Plasmid
CD27 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo939 | Pre-made Human CD27/T14/S152 siRNA oligo Duplex | 939 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo500318 | Pre-made Rat Cd27/Tnfrsf7 siRNA oligo Duplex | 500318 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo21940 | Pre-made Mouse Cd27/S152/Tp55 siRNA oligo Duplex | 21940 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101091633 | Pre-made Cat/Feline CD27 siRNA oligo Duplex | 101091633 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo611674 | Pre-made Dog/Canine CD27 siRNA oligo Duplex | 611674 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo512514 | Pre-made Bovines/Cattle CD27 siRNA oligo Duplex | 512514 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100630357 | Pre-made Equine/Horse CD27 siRNA oligo Duplex | 100630357 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CD27 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T85554-Ab | Human | Anti-Human CD27 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T85554-Ab | Rat | Anti-Rat CD27 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T85554-Ab | Mouse | Anti-Mouse CD27 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T85554-Ab | Cat/Feline | Anti-Cat/Feline CD27 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T85554-Ab | Dog/Canine | Anti-Dog/Canine CD27 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T85554-Ab | Bovines/Cattle | Anti-Bovines/Cattle CD27 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T85554-Ab | Equine/Horse | Anti-Equine/Horse CD27 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CD27 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T85554-Ag | Human | Human CD27 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T85554-Ag | Rat | Rat CD27 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T85554-Ag | Mouse | Mouse CD27 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T85554-Ag | Cat/Feline | Cat/Feline CD27 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T85554-Ag | Dog/Canine | Dog/Canine CD27 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T85554-Ag | Bovines/Cattle | Bovines/Cattle CD27 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T85554-Ag | Equine/Horse | Equine/Horse CD27 VLP (virus-like particle) | HEK293 | Products Developing |
