Explore INSR/CD220 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
| Target ID |
GM-T85435
|
| Target Name |
INSR/CD220
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3643
|
| Gene ID |
100066248 (Equus caballus), 100127108 (Felis catus), 16337 (Mus musculus), 24954 (Rattus norvegicus)
3643 (Homo sapiens), 408017 (Bos taurus), 484990 (Canis lupus familiaris), 706009 (Macaca mulatta)
|
| Target Alternative Names |
INSR,Insr,IR,IR-A,IR-B,CD220,4932439J01Rik,D630014A15Rik,HHF5,ir-A
|
| Uniprot Accession |
P15208,P15127,P06213,Q28516
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index
|
| Disease |
cancer, IgA glomerulonephritis
|
| Disease from KEGG |
MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cGMP-PKG signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Adherens junction, Ovarian steroidogenesis, Regulation of lipolysis in adipocytes, Type II diabetes mellitus, Insulin resistance, Aldosterone-regulated sodium reabsorption, Alzheimer disease
|
| Gene Ensembl |
ENSECAG00000010127, ENSMUSG00000005534, ENSG00000171105, ENSBTAG00000012687, ENSCAFG00845024484, ENSMMUG00000028907
|
| Target Classification |
Kinase
|
Pre-made viral vector of INSR/CD220 cDNA Clones/ORF Plasmid
INSR/CD220 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3643 | Pre-made Human INSR/HHF5/CD220 siRNA oligo Duplex | 3643 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24954 | Pre-made Rat Insr siRNA oligo Duplex | 24954 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16337 | Pre-made Mouse Insr/IR/IR-A siRNA oligo Duplex | 16337 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo706009 | Pre-made Cynomolgus/Rhesus macaque INSR/IR siRNA oligo Duplex | 706009 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100127108 | Pre-made Cat/Feline INSR siRNA oligo Duplex | 100127108 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo484990 | Pre-made Dog/Canine INSR siRNA oligo Duplex | 484990 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo408017 | Pre-made Bovines/Cattle INSR/ir-A siRNA oligo Duplex | 408017 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100066248 | Pre-made Equine/Horse INSR siRNA oligo Duplex | 100066248 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
INSR/CD220 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T85435-Ab | Human | Anti-Human INSR/CD220 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T85435-Ab | Rat | Anti-Rat INSR/CD220 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T85435-Ab | Mouse | Anti-Mouse INSR/CD220 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T85435-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque INSR/CD220 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T85435-Ab | Cat/Feline | Anti-Cat/Feline INSR/CD220 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T85435-Ab | Dog/Canine | Anti-Dog/Canine INSR/CD220 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T85435-Ab | Bovines/Cattle | Anti-Bovines/Cattle INSR/CD220 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T85435-Ab | Equine/Horse | Anti-Equine/Horse INSR/CD220 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
INSR/CD220 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T85435-Ag | Human | Human INSR/CD220 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T85435-Ag | Rat | Rat INSR/CD220 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T85435-Ag | Mouse | Mouse INSR/CD220 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T85435-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque INSR/CD220 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T85435-Ag | Cat/Feline | Cat/Feline INSR/CD220 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T85435-Ag | Dog/Canine | Dog/Canine INSR/CD220 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T85435-Ag | Bovines/Cattle | Bovines/Cattle INSR/CD220 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T85435-Ag | Equine/Horse | Equine/Horse INSR/CD220 VLP (virus-like particle) | HEK293 | Products Developing |
