Explore KCNA1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008]
| Target ID |
GM-T85272
|
| Target Name |
KCNA1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3736
|
| Gene ID |
100051648 (Equus caballus), 101093364 (Felis catus), 16485 (Mus musculus), 24520 (Rattus norvegicus)
3736 (Homo sapiens), 486732 (Canis lupus familiaris), 538703 (Bos taurus), 711718 (Macaca mulatta)
|
| Target Alternative Names |
AEMK,EA1,HBK1,HUK1,KCNA1,KV1.1,Kca1-1,Kcna,Kcna1,Kcpvd,Kv1.1,MBK1,MK1,Mk-1,Potassium voltage-gated channel subfamily A member 1,RBK1,Shak,Voltage-gated K(+) channel HuKI,Voltage-gated potassium channel HBK1,Voltage-gated potassium channel subunit Kv1.1,mceph
|
| Uniprot Accession |
P16388,P10499,Q09470
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Gene Ensembl |
ENSMUSG00000047976, ENSG00000111262, ENSCAFG00845030371, ENSMMUG00000053174
|
| Target Classification |
Ion Channel
|
Pre-made viral vector of KCNA1 cDNA Clones/ORF Plasmid
KCNA1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3736 | Pre-made Human KCNA1/EA1/MK1 siRNA oligo Duplex | 3736 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24520 | Pre-made Rat Kcna1/Kcna/Kcpvd siRNA oligo Duplex | 24520 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16485 | Pre-made Mouse Kcna1/MBK1/Mk-1 siRNA oligo Duplex | 16485 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo711718 | Pre-made Cynomolgus/Rhesus macaque KCNA1 siRNA oligo Duplex | 711718 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101093364 | Pre-made Cat/Feline KCNA1 siRNA oligo Duplex | 101093364 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo486732 | Pre-made Dog/Canine KCNA1 siRNA oligo Duplex | 486732 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo538703 | Pre-made Bovines/Cattle KCNA1 siRNA oligo Duplex | 538703 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051648 | Pre-made Equine/Horse KCNA1 siRNA oligo Duplex | 100051648 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
KCNA1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T85272-Ab | Human | Anti-Human KCNA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T85272-Ab | Rat | Anti-Rat KCNA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T85272-Ab | Mouse | Anti-Mouse KCNA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T85272-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque KCNA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T85272-Ab | Cat/Feline | Anti-Cat/Feline KCNA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T85272-Ab | Dog/Canine | Anti-Dog/Canine KCNA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T85272-Ab | Bovines/Cattle | Anti-Bovines/Cattle KCNA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T85272-Ab | Equine/Horse | Anti-Equine/Horse KCNA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
KCNA1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T85272-Ag | Human | Human KCNA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T85272-Ag | Rat | Rat KCNA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T85272-Ag | Mouse | Mouse KCNA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T85272-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque KCNA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T85272-Ag | Cat/Feline | Cat/Feline KCNA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T85272-Ag | Dog/Canine | Dog/Canine KCNA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T85272-Ag | Bovines/Cattle | Bovines/Cattle KCNA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T85272-Ag | Equine/Horse | Equine/Horse KCNA1 VLP (virus-like particle) | HEK293 | Products Developing |
