Explore CCR7/CD197 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
| Target ID |
GM-T84981
|
| Target Name |
CCR7/CD197
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
1236
|
| Gene ID |
100067673 (Equus caballus), 101084327 (Felis catus), 1236 (Homo sapiens), 12775 (Mus musculus) 287673 (Rattus norvegicus), 491011 (Canis lupus familiaris), 510668 (Bos taurus), 574231 (Macaca mulatta)
|
| Target Alternative Names |
BLR2,C-C CKR-7,C-C chemokine receptor type 7,CC-CKR-7,CCR-7,CCR7,CD197,CDw197,CMKBR7,Ccr7,Cdw197,Cmkbr7,EBI1,EBV-induced G-protein coupled receptor 1),Ebi1h,Epstein-Barr virus-induced G-protein coupled receptor 1 (EBI1,MIP-3 beta receptor
|
| Uniprot Accession |
P32248,P47774,Q5MD62
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway
|
| Gene Ensembl |
ENSECAG00000004945, ENSG00000126353, ENSMUSG00000037944, ENSCAFG00845007930, ENSBTAG00000015133, ENSMMUG00000002102
|
| Target Classification |
GPCR, Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of CCR7/CD197 cDNA Clones/ORF Plasmid
CCR7/CD197 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1236 | Pre-made Human CCR7/BLR2/EBI1 siRNA oligo Duplex | 1236 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo287673 | Pre-made Rat Ccr7 siRNA oligo Duplex | 287673 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12775 | Pre-made Mouse Ccr7/EBI1/CCR-7 siRNA oligo Duplex | 12775 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574231 | Pre-made Cynomolgus/Rhesus macaque CCR7 siRNA oligo Duplex | 574231 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101084327 | Pre-made Cat/Feline CCR7 siRNA oligo Duplex | 101084327 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo491011 | Pre-made Dog/Canine CCR7 siRNA oligo Duplex | 491011 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo510668 | Pre-made Bovines/Cattle CCR7 siRNA oligo Duplex | 510668 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100067673 | Pre-made Equine/Horse CCR7 siRNA oligo Duplex | 100067673 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CCR7/CD197 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T84981-Ab | Human | Anti-Human CCR7/CD197 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T84981-Ab | Rat | Anti-Rat CCR7/CD197 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T84981-Ab | Mouse | Anti-Mouse CCR7/CD197 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T84981-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CCR7/CD197 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T84981-Ab | Cat/Feline | Anti-Cat/Feline CCR7/CD197 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T84981-Ab | Dog/Canine | Anti-Dog/Canine CCR7/CD197 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T84981-Ab | Bovines/Cattle | Anti-Bovines/Cattle CCR7/CD197 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T84981-Ab | Equine/Horse | Anti-Equine/Horse CCR7/CD197 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
CCR7/CD197 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T84981-Ag | Human | Human CCR7/CD197 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T84981-Ag | Rat | Rat CCR7/CD197 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T84981-Ag | Mouse | Mouse CCR7/CD197 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T84981-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CCR7/CD197 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T84981-Ag | Cat/Feline | Cat/Feline CCR7/CD197 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T84981-Ag | Dog/Canine | Dog/Canine CCR7/CD197 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T84981-Ag | Bovines/Cattle | Bovines/Cattle CCR7/CD197 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T84981-Ag | Equine/Horse | Equine/Horse CCR7/CD197 VLP (virus-like particle) | HEK293 | Products Developing |