Explore SLC12A3 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T84886
|
| Target Name |
SLC12A3
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
6559
|
| Gene ID |
100051953 (Equus caballus), 101082284 (Felis catus), 20497 (Mus musculus), 404171 (Bos taurus)
478118 (Canis lupus familiaris), 54300 (Rattus norvegicus), 6559 (Homo sapiens), 703090 (Macaca mulatta)
|
| Target Alternative Names |
NCC,NCCT,Na-Cl cotransporter (NCC),Na-Cl symporter,SLC12A3,Slc12a3,Solute carrier family 12 member 3,TSC,Thiazide-sensitive sodium-chloride cotransporter
|
| Uniprot Accession |
P59158,P55018,P55017
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Gene Ensembl |
ENSECAG00000014101, ENSMUSG00000031766, ENSBTAG00000006630, ENSCAFG00845003721, ENSG00000070915, ENSMMUG00000004812
|
Pre-made viral vector of SLC12A3 cDNA Clones/ORF Plasmid
SLC12A3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6559 | Pre-made Human SLC12A3/NCC/TSC siRNA oligo Duplex | 6559 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo54300 | Pre-made Rat Slc12a3/NCC/TSC siRNA oligo Duplex | 54300 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo20497 | Pre-made Mouse Slc12a3/NCC/TSC siRNA oligo Duplex | 20497 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo703090 | Pre-made Cynomolgus/Rhesus macaque SLC12A3 siRNA oligo Duplex | 703090 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101082284 | Pre-made Cat/Feline SLC12A3 siRNA oligo Duplex | 101082284 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo478118 | Pre-made Dog/Canine SLC12A3 siRNA oligo Duplex | 478118 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo404171 | Pre-made Bovines/Cattle SLC12A3 siRNA oligo Duplex | 404171 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051953 | Pre-made Equine/Horse SLC12A3 siRNA oligo Duplex | 100051953 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
SLC12A3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T84886-Ab | Human | Anti-Human SLC12A3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T84886-Ab | Rat | Anti-Rat SLC12A3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T84886-Ab | Mouse | Anti-Mouse SLC12A3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T84886-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SLC12A3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T84886-Ab | Cat/Feline | Anti-Cat/Feline SLC12A3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T84886-Ab | Dog/Canine | Anti-Dog/Canine SLC12A3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T84886-Ab | Bovines/Cattle | Anti-Bovines/Cattle SLC12A3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T84886-Ab | Equine/Horse | Anti-Equine/Horse SLC12A3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
SLC12A3 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T84886-Ag | Human | Human SLC12A3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T84886-Ag | Rat | Rat SLC12A3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T84886-Ag | Mouse | Mouse SLC12A3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T84886-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SLC12A3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T84886-Ag | Cat/Feline | Cat/Feline SLC12A3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T84886-Ag | Dog/Canine | Dog/Canine SLC12A3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T84886-Ag | Bovines/Cattle | Bovines/Cattle SLC12A3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T84886-Ag | Equine/Horse | Equine/Horse SLC12A3 VLP (virus-like particle) | HEK293 | Products Developing |
