Explore TrkB/NTRK2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
| Target ID |
GM-T84703
|
| Target Name |
TrkB/NTRK2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
4915
|
| Gene ID |
100061700 (Equus caballus), 101101347 (Felis catus), 18212 (Mus musculus), 25054 (Rattus norvegicus)
484147 (Canis lupus familiaris), 4915 (Homo sapiens), 505824 (Bos taurus), 709757 (Macaca mulatta)
|
| Target Alternative Names |
BDNF/NT-3 growth factors receptor,DEE58,EIEE58,GP145-TrkB,GP145-TrkB (Trk-B),GP145-TrkB/GP95-TrkB,NTRK2,Neurotrophic tyrosine kinase receptor type 2,Ntrk2,OBHD,RATTRKB1,TRKB,TRKB1,Tkrb,Trk-B,TrkB,TrkB tyrosine kinase,Tropomyosin-related kinase B,trk-B,trkB
|
| Uniprot Accession |
P15209,Q63604,Q16620
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
MAPK signaling pathway, Ras signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, Neurotrophin signaling pathway
|
| Gene Ensembl |
ENSECAG00000011815, ENSMUSG00000055254, ENSCAFG00845005371, ENSG00000148053, ENSBTAG00000010647, ENSMMUG00000023117
|
| Target Classification |
Kinase, Tumor-associated antigen (TAA)
|
Pre-made viral vector of TrkB/NTRK2 cDNA Clones/ORF Plasmid
TrkB/NTRK2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4915 | Pre-made Human NTRK2/OBHD/TRKB siRNA oligo Duplex | 4915 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25054 | Pre-made Rat Ntrk2/Tkrb/trkB siRNA oligo Duplex | 25054 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18212 | Pre-made Mouse Ntrk2/Tkrb/trkB siRNA oligo Duplex | 18212 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo709757 | Pre-made Cynomolgus/Rhesus macaque NTRK2 siRNA oligo Duplex | 709757 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101101347 | Pre-made Cat/Feline NTRK2 siRNA oligo Duplex | 101101347 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo484147 | Pre-made Dog/Canine NTRK2 siRNA oligo Duplex | 484147 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo505824 | Pre-made Bovines/Cattle NTRK2/TrkB/Trk-B siRNA oligo Duplex | 505824 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100061700 | Pre-made Equine/Horse NTRK2 siRNA oligo Duplex | 100061700 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TrkB/NTRK2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T84703-Ab | Human | Anti-Human TrkB/NTRK2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T84703-Ab | Rat | Anti-Rat TrkB/NTRK2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T84703-Ab | Mouse | Anti-Mouse TrkB/NTRK2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T84703-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TrkB/NTRK2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T84703-Ab | Cat/Feline | Anti-Cat/Feline TrkB/NTRK2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T84703-Ab | Dog/Canine | Anti-Dog/Canine TrkB/NTRK2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T84703-Ab | Bovines/Cattle | Anti-Bovines/Cattle TrkB/NTRK2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T84703-Ab | Equine/Horse | Anti-Equine/Horse TrkB/NTRK2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
TrkB/NTRK2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T84703-Ag | Human | Human TrkB/NTRK2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T84703-Ag | Rat | Rat TrkB/NTRK2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T84703-Ag | Mouse | Mouse TrkB/NTRK2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T84703-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TrkB/NTRK2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T84703-Ag | Cat/Feline | Cat/Feline TrkB/NTRK2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T84703-Ag | Dog/Canine | Dog/Canine TrkB/NTRK2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T84703-Ag | Bovines/Cattle | Bovines/Cattle TrkB/NTRK2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T84703-Ag | Equine/Horse | Equine/Horse TrkB/NTRK2 VLP (virus-like particle) | HEK293 | Products Developing |
