Explore GBA/GBA1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
| Target ID |
GM-T84173
|
| Target Name |
GBA/GBA1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2629
|
| Gene ID |
100063514 (Equus caballus), 101091083 (Felis catus), 14466 (Mus musculus), 2629 (Homo sapiens)
537087 (Bos taurus), 612206 (Canis lupus familiaris), 684536 (Rattus norvegicus), 719103 (Macaca mulatta)
|
| Target Alternative Names |
Acid beta-glucosidase,Alglucerase,Beta-glucocerebrosidase (Beta-GC),Beta-glucosylceramidase 1,Cholesterol glucosyltransferase (SGTase),Cholesteryl-beta-glucosidase,D-glucosyl-N-acylsphingosine glucohydrolase,GBA,GBA1,GC,GCB,GCase,GLUC,Gba,Gba1,Glucosylceramidase beta 1,Imiglucerase,Lysosomal acid GCase,Lysosomal acid glucosylceramidase,Lysosomal cholesterol glycosyltransferase,Lysosomal galactosylceramidase,Lysosomal glycosylceramidase,betaGC
|
| Uniprot Accession |
P17439,P04062,Q2KHZ8
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Metabolic pathways, Lysosome, Sphingolipid metabolism
|
| Gene Ensembl |
ENSECAG00000022786, ENSMUSG00000028048, ENSG00000177628, ENSBTAG00000014841, ENSCAFG00845012760, ENSMMUG00000008507
|
Pre-made viral vector of GBA/GBA1 cDNA Clones/ORF Plasmid
GBA/GBA1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2629 | Pre-made Human GBA1/GBA/GCB siRNA oligo Duplex | 2629 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo684536 | Pre-made Rat Gba1/Gba siRNA oligo Duplex | 684536 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14466 | Pre-made Mouse Gba1/GC/Gba siRNA oligo Duplex | 14466 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo719103 | Pre-made Cynomolgus/Rhesus macaque GBA1/GBA siRNA oligo Duplex | 719103 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101091083 | Pre-made Cat/Feline GBA1/GBA siRNA oligo Duplex | 101091083 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo612206 | Pre-made Dog/Canine GBA1/GBA siRNA oligo Duplex | 612206 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo537087 | Pre-made Bovines/Cattle GBA1/GBA siRNA oligo Duplex | 537087 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100063514 | Pre-made Equine/Horse GBA1/GBA siRNA oligo Duplex | 100063514 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
GBA/GBA1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T84173-Ab | Human | Anti-Human GBA/GBA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T84173-Ab | Rat | Anti-Rat GBA/GBA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T84173-Ab | Mouse | Anti-Mouse GBA/GBA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T84173-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque GBA/GBA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T84173-Ab | Cat/Feline | Anti-Cat/Feline GBA/GBA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T84173-Ab | Dog/Canine | Anti-Dog/Canine GBA/GBA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T84173-Ab | Bovines/Cattle | Anti-Bovines/Cattle GBA/GBA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T84173-Ab | Equine/Horse | Anti-Equine/Horse GBA/GBA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GBA/GBA1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T84173-Ag | Human | Human GBA/GBA1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T84173-Ag | Rat | Rat GBA/GBA1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T84173-Ag | Mouse | Mouse GBA/GBA1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T84173-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque GBA/GBA1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T84173-Ag | Cat/Feline | Cat/Feline GBA/GBA1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T84173-Ag | Dog/Canine | Dog/Canine GBA/GBA1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T84173-Ag | Bovines/Cattle | Bovines/Cattle GBA/GBA1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T84173-Ag | Equine/Horse | Equine/Horse GBA/GBA1 recombinant protein | Mammalian cell | Detail |
