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Target
sublocation: Transmembrane Protein.
This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]
| Target ID |
GM-T83813
|
| Target Name |
HTR2C
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3358
|
| Gene ID |
100057852 (Equus caballus), 101099620 (Felis catus), 15560 (Mus musculus), 25187 (Rattus norvegicus) 3358 (Homo sapiens), 407134 (Bos taurus), 450240 (Canis lupus familiaris), 708141 (Macaca mulatta)
|
| Target Alternative Names |
5-HT-1C,5-HT-2C,5-HT1C,5-HT1C),5-HT2C,5-HT2cR,5-HTR2C,5-hydroxytryptamine receptor 1C (5-HT-1C,5-hydroxytryptamine receptor 2C,5HT-1C,5HT1c,5HT2C,5HTR2C,5htr2c,HTR1C,HTR2C,Htr1c,Htr2c,SR1,Serotonin receptor 2C
|
| Uniprot Accession |
P34968,P08909,P28335,Q60F97
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels
|
| Gene Ensembl |
ENSECAG00000021540, ENSMUSG00000041380, ENSG00000147246, ENSCAFG00845015792, ENSMMUG00000009607
|
| Target Classification |
GPCR
|
Pre-made viral vector of HTR2C cDNA Clones/ORF Plasmid
HTR2C siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3358 | Pre-made Human HTR2C/HTR1C/5-HT1C siRNA oligo Duplex | 3358 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25187 | Pre-made Rat Htr2c/5-HT2C/5HT-1C siRNA oligo Duplex | 25187 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo15560 | Pre-made Mouse Htr2c/SR1/5HT1c siRNA oligo Duplex | 15560 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo708141 | Pre-made Cynomolgus/Rhesus macaque HTR2C siRNA oligo Duplex | 708141 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101099620 | Pre-made Cat/Feline HTR2C siRNA oligo Duplex | 101099620 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo450240 | Pre-made Dog/Canine HTR2C/5-HT-2C/5-HTR2C siRNA oligo Duplex | 450240 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo407134 | Pre-made Bovines/Cattle HTR2C/5HT2C/5-HT2C siRNA oligo Duplex | 407134 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100057852 | Pre-made Equine/Horse HTR2C siRNA oligo Duplex | 100057852 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
HTR2C antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T83813-Ab | Human | Anti-Human HTR2C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T83813-Ab | Rat | Anti-Rat HTR2C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T83813-Ab | Mouse | Anti-Mouse HTR2C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T83813-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque HTR2C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T83813-Ab | Cat/Feline | Anti-Cat/Feline HTR2C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T83813-Ab | Dog/Canine | Anti-Dog/Canine HTR2C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T83813-Ab | Bovines/Cattle | Anti-Bovines/Cattle HTR2C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T83813-Ab | Equine/Horse | Anti-Equine/Horse HTR2C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
HTR2C VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T83813-Ag | Human | Human HTR2C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T83813-Ag | Rat | Rat HTR2C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T83813-Ag | Mouse | Mouse HTR2C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T83813-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque HTR2C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T83813-Ag | Cat/Feline | Cat/Feline HTR2C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T83813-Ag | Dog/Canine | Dog/Canine HTR2C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T83813-Ag | Bovines/Cattle | Bovines/Cattle HTR2C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T83813-Ag | Equine/Horse | Equine/Horse HTR2C VLP (virus-like particle) | HEK293 | Products Developing |